Analgesics in MOS 1 Flashcards
What are the most effective NSAIDs for pain after oral surgery (currently recommended)?
- ibuprofen
- diclofenac
What comprehensive advice can be given to prescribers of NSAIDs?
prescribe the lowest effective dose for the shortest possible duration
How many NSAIDs are on the global market ?
over 50
Suggest a reason why diclofenac presriptions are more common than ibuprofen
this is due to only small doses of diclofenac being available OTC
Ibuprofen is an effective analgesic in the control of post-operative dental pain. True or false
True
Aspirin is mainly used for…
cardiovascular treatment
What is the half-life of aspirin ?
15 minutes
What is the half life of naproxen?
12-15 hours
What is the benefit of using ibuprofen over fenoprofen?
it has less gastrointestinal side effects
What are the uses of dexketoprofen?
mild to moderate pain
Ketoprofen and dexketoprofen have similar anti-inflammatory properties to ibuprofen. True or False
true
Diclofenac and acelofenac have a similar efficacy to …
naproxen
Diclofenac potassium is _________ release
immediate
Diclofenac sodium is ____ release
slow
Diclofenac potassium was developed to manage what type of pain?
migraine pain
What type of diclofenac is more frequently prescribed?
diclofenac sodium
What preparation of diclofenac is more useful for management of post-operative pain?
diclofenac potassium
What is the main use of Etodolac?
licensed for symptomatic relief of arthritis
What is the half life of etodolac ?
7 hours
Indometacin has equal or superior efficacy to naproxen, however, it has a higher incidence of side effects. List some of these side effects
- headache
- dizziness
- GI disturbances
What is the half life of indometacin ?
4.5 - 6 hours
Mefenamic acid has ____ anti-inflammatory properties.
minor
What is the half life of mefenamic acid ?
3-4 hours
Mefenamic acid is often associated with what side effects?
- diarrhoea
- haemolytic anaemia
What is meloxicam currently licensed for use on?
- short term pain relief in osteoarthritis
- long term treatment of rheumatoid arthritis and ankylosing spondylitis
What is the half life of meloxicam ?
13-20 hours
Phenylbutazone is used for …
ankylosing spondylitis
Why is the use of phenylbutazone restricted to specialist treatment of severe cases where other treatments have failed?
this is because it is associated with serious side effects
What permits the once daily administration of piroxicam?
long duration of action
What is the half life of piroxicam ?
30-86 hours
What are the adverse effects of piroxicam ?
- more GI disturbances than other NSAIDs
- severe skin reactions
Tenoxicam also has a long duration of action that permits 1x daily administration. True or false
true
Ketorolac and parecoxib are licensed for __________ management of post operative pain
short term
Parecoxib is _____ selective
COX-2
Celecoxib and etoricoxib are ____ selecitive
COX-2
Celecoxib and etoricoxib are licensed for treatment of …
- arthritis
- ankylosing spondylitis
What coxib is licensed for treatment of acute gout?
etoricoxib
Outline the available formations of ibuprofen
- 200mg, 400mg, 600mg, 800mg slow release tablets
- 100mg/5ml oral suspension (available sugar free preparations)
- 600mg effervescent sachets
- topical preparations
What is the recommended dose of ibuprofen for adults and children over 12 years old?
300-400mg 3-4x daily
increased if necessary to a maximum 2.4g daily, administered by mouth
Diclofenac potassium is on the DPF. True or false
false
Diclofenac potassium has fewer routes of administration and is more expensive. True or false
True
What formulation of diclofenac potassium is available OTC?
12.5mg tablet for 3 day usage
What are the available formulations of diclofenac sodium?
- 12.5mg, 25mg and 50 mg tablets
- 75mg and 100mg slow release formulations
- dispersible tablets (50mg equivalent)
- 12.5mg, 25mg, 50mg and 100mg suppositories
- 75mg IM injection
- 75mg IV infusion
- Topical preparations
What is the recommended dose of diclofenac sodium for adults ?
75-150mg per 24 hours in 2 or 3 divided doses
administered via mouth or rectum