- Bind to opioid (mu/kappa/sigma/delta) receptors in CNS and peripheral tissues--> Glutamate can no longer release from primary afferent neuron - G protein coupled: agonist leads to membrane hyperpolarization, inhibition of Adenyly Cyclase, reduction in cAMP, activation of PLC

Analgesics Flashcards by Jordan Oddo

MOA

Bind to opioid (mu/kappa/sigma/delta) receptors in CNS and peripheral tissues–> Glutamate can no longer release from primary afferent neuron
G protein coupled: agonist leads to membrane hyperpolarization, inhibition of Adenyly Cyclase, reduction in cAMP, activation of PLC

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