Anal cancer Flashcards
name the primary tx option for anal cancer
EBRT - 50.4Gy in 28#
ChemoRad
palliative EBRT
//opp A/P 20Gy in 5 #
name 3 aetiological factors for anal cancer
gender- women
HPV
Age - older
main histology of anal tumours
squamous cell carcinoma
name 2 clinical trials for anal cancer
PLATO -ACT4
PLATO-ACT5
what is PLATO-ACT4 trailing
reducing number of RT #s and reducing RT dose for pt receiving CHEMORAD = with fewer #s and less dose still achieving similar contour and more convenient for pts in 4 weeks instead of 5.
what is PLATO-ACT5 trailing
giving higher RT dose to pts with locally advanced disease
= higher dose had no significant impact on pt toxicities and QoL suggesting higher dose more beneficial for local control without worsened effect.