Anal Cancer

Question 1

What risk factor increases the risk of developing anal cancer 40 fold?

Answer 1

HIV

Question 2

Which chemotherapy regimen is used for definitive treatment of anal cancer?

Answer 2

5FU + Mitomycin

Question 3

What is the definitive treatment modality for anal cancer?

Answer 3

Concurrent Chemo RT

Question 4

When is surgery employed for anal cancer?

Answer 4

Salvage only

Question 5

Which preventative measure can lower the risk of anal cancer by 75%?

Answer 5

Quadravalent HPV vaccine to HPV 6, 11, 16, 18

Question 6

Which HPV virus is implicated in anal cancer?

Answer 6

HPV 16

Question 7

Define T3 in anal cancer

Answer 7

Lesion larger than 5 cm

Question 8

Dose of 5FU + Mitomycin

Answer 8

5-fluorouracil 1000 mg/m2 day 1-4 and day 29-32

Mitomycin 15 mg/m2 day 1 and day 29

Question 9

Define Stage III disease

Answer 9

N1 or T4

Question 10

What should prompt surgical resection of anal cancer?

Answer 10

Persistent disease at 26 weeks

Progressive disease during therapy

Question 11

Which chemotherapy agents are effective for metastatic anal cancer?

Answer 11

5-FU and cisplatin

Question 12

How do you surgically manage adenocarcinoma of the anus?

Answer 12

same as rectal
APR
abdominoperineal resection

Question 13

What anal cancer can you treat with surgery only?

Answer 13

T1 lesion smaller than 2 cm