Anaesthetics

Question 1

IV anaesthetics example?

Answer 1

Propofol, ketamine

Question 2

Mechanism of anaesthetics on inhibitory neurotransmitters?

Answer 2

most anaesthetics increase sensitivity to GABA or glycine -> more Cl- enters -> hyperpolarisation and decrease excitability

Question 3

Anaesthetics- mechanism excitatory neurotransmitters?

Answer 3

Ketamine, Nitrous oxide and xenon block glutamate NMDA receptors -> decreased excitability

Question 4

Anaesthetic ADRs?

Answer 4

CVS and resp depression (fluranes, propofol, opioids, benzos)
Malignant hyperthermia
Post-op cognitive dysfunction
Anaphylaxis

Question 5

Fluranes ADRs?

Answer 5

Hypotension (decreased vascular resistance), increased ICP, arrythmias

Question 6

Examples of inhalational anaesthetics?

Answer 6

Fluranes, N2O, xenon

Question 7

Nitrous oxide- ADR?

Answer 7

Diffusion hypoxia- especially in resp compromised patients, give high flow oxygen after procedure to prevent it