Anaemias Flashcards
what cytotoxic medication can be used to reduce the frequency of sickle cell crisis?
Hydroxycarbamide
What anaemia are people wiht G6DP deficiency more likely to develop
Haemolytic anemia
Antibiotic classes that have am definite risk of haemolysis in G6DP deficieny
Flurorquinolones, quinolones, sulfonamide e.g. co-trimoxazole
What immunoglobulin can be used for aplastic anaemia
Antithrombocyte - give IV over 12-18 hours
Why can darbopoetin alfa be administered less frequently than epoetin?
longer half life
The MHRA alert regarding risk of severe cutaneous reactions (SJS/TENS), haemoglobin concentration, tumour progression and survival in patinets with cancer are all related to what drug class?
Epoetins
How should Epos be prescribed?
By brand - they are biological medicines
MHRA alert regarding parenteral iron preparations>
risk of hypersensitivity reactions
After a iron IV infusion, when should oral iron be started?
At least 5 days after
When haemoglobin levels are back into range following iron replacement therapy, how long should maintanence dosing continue to replenish iron store?
3 months
What deficiencies often lead to megaloblastic anaemias
Vitamin B12 or folate
Why should folate not be administered without concurrent B12 in patients with megoblastic anaemia?
Risk of neuropathy
What type of anaemia may result in degeneration of the spinal cord if folic acid is given alone?
Pernicious anaemia
What is the antidocte for iron overload
Desferrioxamine (can be given at same time as blood transfusion but not in same line or mixed with blood)
what other metal can desferrioxamine be used to treat overload of>
Aluminium
