Anaemias

Question 0

Megaloblastic anaemia

Answer 0

Most common cause macrocyclic anaemia
Deficiency vit B12, folic acid, both
B12 deficiency also neurological symptoms
Inc. pernicious anaemia
Can be caused by gastric bypass, reduced absorption

Question 1

Macrocytic anaemia examples

Answer 1

Megaloblastic anaemia
Hypothyroidism
Alcoholism
Methotrexate (inhibits DNA replication)

Question 2

Pernicious anaemia

Answer 2

Macrocytic, megaloblastic anaemia
Lack of intrinsic factor
So can’t absorb vit B12
Due to autoimmune vs parietal cells, or vs IF itself

Question 3

Hypothyroidism

Answer 3

Causes macrocytic anaemia

Question 4

Microcytic Anaemia

Answer 4

Iron deficiency

Haemoglobin synthesis failure

Question 5

Iron deficiency anaemia

Answer 5

Macrocytic anaemia
Insufficient uptake / absorption
Blood loss from GI tract
Worldwide - parasitic causes

Question 6

Normocytic anaemia

Answer 6

Acute blood loss
Anaemia of chronic disease
Aplastic anaemia (bone marrow failure)
Haemolytic anaemia