Amphetamines

Question 1

Amphetamines

Answer 1

-reverses the direction
-causes the sporadic release of DA + NE
-inhibits the enzymes that break down NE + DA
-all three increase DA + NE

Question 2

Why do we use Amphetamines for ADHD?

Answer 2

-all symptoms of ADHD can be linked to an area of the brain
-Prefrontal cortex is asleep and needs to wake up to pay attention

Question 3

Drugs used to treat ADHD?

Answer 3

Aderall + Ritalin (not as commonly used bc of heart problems)

Question 4

Areas of the brain linked to ADHD

Answer 4

• Dorsal Acc - Selective Attention
• Pre Frontal Cortex - hyperactive symptoms
  -Dorsal Lateral PFC - sustained attention + problem solving
  -Orbitofrontal cortex - impulsive symptoms

Question 5

What do ADHD meds do?

Answer 5

–Low levels of NE in people with ADHD. Ritalin + Adderall increase NE
- Locus Correus talks to Prefrontal Cortex -> makes a lot of NE (Adderall blocks NE transporter)
-glutamate from a2 NE receptor depolarizes cell

Question 6

Ritalin & Cocaine

Answer 6

both block DAT, causing dopamine to build up in the synapse

Question 7

What happens if you take Adderall and you weren’t prescribed?

Answer 7

-adderall is fixing an imbalance so it affects people differently for someone who doesn’t have ADHD
-theres an optimal level of NE + DA that its optimal for focus. An excessive amount of NE+DA makes you stressed and too little makes you fatigued

Question 8

Amphetamines & Seizures

Answer 8

• seizures are caused by excitotoxicity which is too much glutamate in the synapse
• Theres an increase glutamate release from Adderall and too much can cause a seizure