Amphetamine-like indirect sympathomimetics Flashcards
1
Q
What is the MOA of Amphetamine-like indirect sympathomimetic drugs?
A
MOA: Displaces stored catecholamines
affects NE release and reuptake
– Uptake via NET and VMAT à displaces NE in vesicles à NE release*
2
Q
What is the Clinical Use of Amphetamine-like indirect sympathomimetic drugs?
A
– Hypotension
– Nasal decongestants (Vasoconstriction in nasal mucosa)
– CNS effects
3
Q
What is the adverse effects of Amphetamine-like indirect sympathomimetic drugs?
A
Cardiovascular: (increased BP, increased HR, cardiac arrhythmias)
CNS (paranoia, insomnia, headaches, nervousness)
