Adrenergic Durugs Flashcards
What are the types of adrenergic drugs?
Sympathomimetic
Sympatholytic
What are the types of sympathomimetic drugs?
Endogenous catecholamines
a agonists (nonselective and a1 selective)
b agonist (nonselective and B1-B3 selective)
What are the types of sympatholytic drugs?
a antagonists (nonselective and a1selective)
a2 agonist
b antagonist (nonselective and B1 selective)
What is the MOA of Endogenous catecholamines?
– Agonist at a and b1 receptors
– Agonist at a, b1 and b2 receptors
What is the clinical use of Endogenous catecholamines?
Cardiovascular emergencies: Hypotension (NE Tx); Cardiac Arrest (EPI Tx)
Anaphylaxis: CDV and bronchospasm
What is the adverse effects of Endogenous catecholamines?
Arrhythmias
hypertension
What is the MOA of Nonselective a-agonists and a1-agonists?
Stimulate a1 and a2 receptors with different selectivity
What are the clinical uses of a1-agonists?
Hypotention (due to vasocontriction)
Nasal decongestants (congestion due to vasoconstriction in nasal mucosa)
Ocular irritation/eye redness (due to constriction of conjunctivial blood vessels)
Mydriatic agent
What are the adverse effects of Nonselective a-agonists and a1-agonists?
HTN
Rebound Hyperemia
What is the MOA of Nonselective b-agonists and b1-agonists?
Stimulate b1 and b2 receptors with different selectivity
What are the clinical uses b1-agonists?
– AV block (b1 stimulation increases AV conduction)
– Bradycardia (b1 stimulation increases HR)
– Acute heart failure
– Cardiogenic shock
What are the adverse effects of Nonselective b-agonists and b1-agonists?
Tachycardia and other arrhythmias
What is the MOA of b2-agonists?
stimulate b2 receptors
What are the clinical uses of b2-agonists?
Asthma/COPD (via Bronchodilation)
What are the adverse effects of b2-agonists?
Tremor (stimulation of b2 on SKM)
Tachycardia/arrythmias (cardiac stimulation, B2A not 100% selective)
