AMK rheum Flashcards

1
Q

rheumatoid arthtrits more specific antibody

A

CCP

specific mean not seen in many other condtions

sensitive most likely to be positive as most senstive to be detected

more sensitive is rheumatoi facotr

if rf negative then look for anti-ccp

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2
Q

do you take methotraxate and folic acid together

A

no 24hr apart

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3
Q

MX of rheum

A

1st present
refer to rhuem and NSAID
dont give steriods as can mask sx

confrimed dx
then give steriods for flares and DMARS

DAS28 score

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4
Q

chlamydia synovial joint fluid sample would show what - leads to reactive arthritis

A

sterile fluid with high WCC

cnat see cant pee cant climb tree

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5
Q

most common cause of septic arthritis

A

staph a

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6
Q

symmetrical polyarthriits, asymetricla oligoarthritis, dip joitn disease adn nail changes such as pitting adn onycholysis what is seen on xray fro this conditon and what is tx

A

dmard

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7
Q

when do oyu measure urate post gout

A

2w

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8
Q

abx for septic arthritis how long

A

4-6weeks - local guidlines and theatre for joint washout

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9
Q

kochers criteria in children for septic arthrtisi vs transietn synovitis what is the criteria

A

non-weight bearing
esr over 40
fever over 38.5
wcc over 12000

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10
Q

what ix supports ank spondy

A

pelvic x ray sacroiltiis

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11
Q

ank spond

A

mronig stiff
improve with activity
extraarticular features

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12
Q

muscular abck pain presnet slike

A

pain worse when moving
localised pain

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13
Q

neurological pain

A

radiates along dermatome
parasethesia

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14
Q

bony pain

A

worse with movement
neurolgoical sx

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15
Q

most senstiive sle

A

ANA

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16
Q

most specific autoanitbodu for sle

A

anti-dsDNA
anti-smith

17
Q

tx for SLE

A

hydroxycholorquine and NSAID

18
Q

derm features of sle

A

malar rash
discoid rash

19
Q

cardiac features of sle

A

pericarditis
myocarditis
raynauds

20
Q

polymyalgia rheumatica

A

pain stiffnes in prox muscles
morning stiffness
no weakness
systemic features - fever, fatigue, weight loss

over 60 females

21
Q

1st line polymyalgia

A

steriods such as pred

22
Q

fibromyalgia

A

pain and fatigue
widespread tender spots
30-50yr female

cbt lifestyle

23
Q

poly dermatomysositis sx

A

bilateral proximal muscle pain
weakness
systemic sx and raynauds

females
BLOOC malig

24
Q

polymyositis autoanitbody

A

anti-Jo1

gold standard ix is muscl ebiopsy

25
Q

tx for myositis

A

steriods

26
Q

lambert eaton synrome

A

autoimune agaisnt ca channels - ascending - improves with use

Antibodies to presynaptic voltage gated calcium channels of the P/Q–type

27
Q

guillian barre syndrome

A

ascending paraetheisa
peripherla nerve demyeliantion

28
Q

most appropraite dose for steriods for giant cell arthritis

A

40-60mg - pred
bone protection?
ppi?
aspirin

visual sx and refer to opahtlomology

29
Q

bloods in temproal arthritis show

A

nromocytic mornochormic anaemai and high esr

USS shows hypoechocic halo sign

need biopsy gold

30
Q

methotraxate how much do you give dose wise weekly

A

7.5mg

31
Q

how much folic acid do you co-prescrib ewith methotrexate

A

5mg
avoid preg for 6m as well as men too
monitor FBC, UandE and LFT ( risk of liver fibrosis)

32
Q

hydroxychloroquine what major risk

A

cause bull eys retinopathy - yearly screening

33
Q

sulfasalazinen se

A

reduced sperm count
cautions - aspirin allergy and GPD6 def berfore starting
safe in preg and breastfeeeding - one of the onyl

34
Q

only DMARD safe in preg and breastfeeding

A

sulfasalazine