Amitriptyline Flashcards
1
Q
Class of Amitriptyline
A
Tricyclics
2
Q
Mechanism of Amitriptyline
A
Inhibitor of pre-synaptic NA + S reuptake transporters —> + S&NA in synaptic cleft
3
Q
Indications for Amitriptyline
A
- depression
- neuralgia
- migraine
4
Q
Contraindications for Amitriptyline
A
- elderly + suicide
- MI
- H block
- bipolar manic phase
5
Q
Side effects of Amitriptyline
A
- cardiotoxic
- hyponatraemia
- neuroleptic malignant syndrome
6
Q
Why should MAOIs NOT be co-prescribed with Amitriptyline
A
Hypertensive hyponatraemia
7
Q
Amitriptyline is mostly excreted via
A
Urine
8
Q
Withdrawal should be
A
Slow
9
Q
Abx to avoid in SSRI to avoid serotonin syndrome
A
clozapine
