Amiodrarome

Question 1

Amiodrome Indication

Answer 1

Shockable Cardiac arrest after first dose of adrenaline.

Adults with sustained VT that doesn’t meet cardioversion.

Moderate cardiovascular compromise as a result of atrial fib / flutter

Question 2

Amiodrome Contra induction

Answer 2

VT Secondary to cyclic antidepressant poisoning. In this setting amiodrome can be associated with worsening of shock without resolution of the rhythm

Question 3

Amiodrome Mechanism

Answer 3

Amiodrome is an antidysrhythmic. It prolongs action potential duration, reduces automaticity and prolongs the refractory period of atrial, nodal and ventricular tissues. This normally mean reduction of electrical conduction and and a reduction of heart rate and stabilisation of SA and AV nodes

Question 4

Amiodrome Dosage

Answer 4

Cardiac arrest:
300mg and second dose of 150mg

Tachycardia arrhythmia;
300mg IV over 30 minutes a further 150mg can be give if it persists