Amiodarone HCI (Cordarone) Flashcards
1
Q
Classification
A
Antidysrythmic agent
2
Q
Mechanism of Action
A
- Acts directly on the myocardium to delay repolarization and increase the duration of the action potential
- Slows sinus rate, increases PR and QT intervals, decreases peripheral vascular resistance
3
Q
Indications
A
- Ventricular arrythmias
- Second-line agent for atrial arrythmias
4
Q
Contraindications
A
- Sick sinus syndrome
- Second- and third-degree heart block
5
Q
Adverse Effects
A
- Burning at the IV site
- Hypotension
- Bradycardia
6
Q
Administration
A
-
V-Fib & Pulseless V-Tach
- Adult: 300 mg IV/IO, may be followed by one dose of 150 mg in 3-5 minutes.
- Peds: 5 mg/kg (max 300 mg), may repeat with 5 mg/kg IV/IO up to 15 mg/kg
-
Relatively Stable Arrythmias such as PVCs, or Wide Complex Tachycardia with a Strong Pulse:
- Adult: 150 mg in 100 mL D5W IV/IO over 10 minutes, may repeat in 10 minutes to a max dose of 2.2 grams over 24 hours
- Peds: 5 mg/kg very slow IV/IO over 20-60 minutes, may repeat 5 mg/kg doses up to 15 mg/kg (max 300 mg)