Amiodarone

Question 1

What class of drug is Amiodorone?

Answer 1

Class III anti arrhythmic agent

Question 2

What is the main mechanism of action of Amiodorone?

Answer 2

Blocking potassium channels which inhibit repolarisation and hence prolong the action potential

• can also block sodium channels

Question 3

Which factors limit the use of amiodorone?

Answer 3

1. Very long half life (20-100 days)
2. Pro arrhythmic effects due to lengthening of QT interval
3. Ideally given in central veins - causes thrombophlebitis

Question 4

What are the main adverse organ impacts of taking amiodorone?

Answer 4

1. Thyroid dysfunction - hypothyroidism and hyperthyroidism
2. Lungs dysfunction - pulmonary fibrosis / pneumonitis
3. Liver fibrosis - liver fibrosis / hepatitis
4. Heart - bradycardia / prolonged QT interval

Question 5

Skin /surface related adverse impacts of taking amiodorone?

Answer 5

1. Corneal deposits
2. ‘Slate-grey appearance’
3. Photosensitivity
4. Thrombophlebitis and injection site reaction
5. Peripheral neuropathy

Question 6

How are patients who take amiodorone monitored?

Answer 6

1. TFT, LFT, U + E, CXR prior to treatment