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MSRA GASTRO > AMINOSALICYLATE DRUGS > Flashcards

AMINOSALICYLATE DRUGS Flashcards

1
Q

Examples

A

sulphasalazine
mesalazine
olsalazine

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2
Q

how does it work?

A

5-aminosalicyclic acid (5-ASA) is released in the colon and is not absorbed. It acts locally as an anti-inflammatory. The mechanism of action is not fully understood but 5-ASA may inhibit prostaglandin synthesis

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3
Q

what is sulphasalazine?

A

a combination of sulphapyridine (a sulphonamide) and 5-ASA

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4
Q

side effects of sulphasalazine?

A

rashes, oligospermia, headache, Heinz body anaemia, megaloblastic anaemia, lung fibrosis

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5
Q

how does mesalazine work?

A

a delayed release form of 5-ASA

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6
Q

side effects of mesalazine

A

side-effects seen in patients taking sulphasalazine are avoided

GI upset, headache, agranulocytosis, pancreatitis*, interstitial nephritis

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7
Q

what is olsalazine?

A

two molecules of 5-ASA linked by a diazo bond, which is broken by colonic bacteria

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8
Q

important side effects

A

agranulocytosis - FBC is a key investigation in an unwell patient taking them.

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9
Q

with which drug is pancreatitis more common

A

mesalazine

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MSRA GASTRO (10 decks)

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