aminoglycosides

Question 1

mechanisms of action

Answer 1

inhibit bacterial protein synthersis (bactericidal)

Question 2

primary uses

Answer 2

aerobic gram negative bacteria (E. coli, Klebsiella, Proteus, Pseudomonas), mycobacteria, & protozoans.
Usually given parenterally: poorly absorbed from GI tract
Occasionally PO to sterilize bowel prior to intestinal surgery

Question 3

adverse effects

Answer 3

: limited use related to potential for serious adverse effects
Pain or inflammation at injection site, rash, fever, nausea, diarrhea, dizziness, tinnitus, Anaphylaxis, nephrotoxicity, neurotoxicity manifesting as ototoxicity, superinfections

Question 4

gentamincin

Answer 4

Primary use: serious respiratory, urinary, nervous, & GI infections
Effective against some strains of MRSA
neomycin: topical infections of skin, eyes, ears
paromomycin, (Humatin): PO to treat parasitic infections
Used with treatment with PCN is contraindicated