Amino acids & peptides Flashcards
Know the expression relating change in Gibbs free energy, change in
enthalpy and change in entropy; and know what each term represents
Be able to interpret a Gibbs free energy plot
Predict from ∆G whether a reaction is spontaneous or not.
Explain how ∆G is different from ∆G’°.
Demonstrate how imposing equilibrium conditions allows the
relationship between standard free energy change and equilibrium
constant to be derived
Describe how understanding free energy changes allows the prediction
of features of a reaction.
Describe three (3) ways an ‘unfavorable’ reaction can be made
favorable.
(By the end of semester) explain why certain ‘unfavorable’ metabolic
reactions are favorable in the cell.
Explain why ATP is considered an “energy rich” molecule.
Draw or identify D and L amino acids
Name/draw/identify each of the 20 naturally occurring amino acids
‘Read’ amino acid sequences in single letter and three letter code
From sequence information, identify the ionizable groups in
polypeptides and draw the structure of their protonated and
deprotonated states.
Calculate the overall charge on a peptide sequence at a given pH
Predict whether a peptide sequence will absorb UV light.
Predict whether a peptide sequence will form disulfide bonds
Interpret the different ways proteins are graphically represented.
Compare the size of a water molecule to a protein
Explain how peptide bond forms and what its physical properties
Be able to identify the N-terminus and C-terminus of a polypeptide
Draw the cis and trans isomers of peptide bonds
Rationalize why the trans isomer is favoured.
Explain how the the ω (omega), φ (phi), ψ (psi) backbone dihedral
angles are defined
Know the values of the ω (omega) dihedral angle for the trans and cis
isomers of the peptide bond
