Amino Acids Flashcards

1
Q

Gluconeogenic amino acid examples

A

Ala, Arg, Asn, Asp, Cys, Glu, Gln, Gly, His, Pro, Ser, Met, Val

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2
Q

Glucogenic/ketogenic aa examples

A

isoleucine, phenylalanine, tyrosine, tryptophan

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3
Q

Ketogenic aa examples

A

leucine, lysine

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4
Q

types of essential aa

A

glucogenic, ketogenic, glucogenic/ketogenic

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5
Q

acidic amino acids

A

aspartic acid, glutamic acid

- negatively charged at body pH

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6
Q

basic aa

A

arginine (most basic), lysine, histidine

- Histidine has no charge at body pH

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7
Q

which form of amino acids found in proteins

A

L-form

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8
Q

Sulfer-containing amino acids

A

methionine, cysteine

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9
Q

conditionally essential amino acids

A

can be made by body, but the capacity for their synthesis is limited and in high states of consumption (i.e. critical illness) deficiency may develop

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10
Q

amino acids with nitrogen side chain

A

Glutamine, asparagine, lysine, histidine, arginine

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11
Q

branched amino acids

A

Valine, isoleucine, leucine

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12
Q

aromatic amino acids

A

tryptophan, tyrosine, phenylalanine

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13
Q

glucogenic amino acids

A

used as substrates for gluconeogenesis

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14
Q

ketogenic aa

A

when broken down, these generate Acetyl CoA and can’t participate in gluconeogenesis but produce ATP through TCA or be used for ketone synthesis

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15
Q

Post-translationally modified amino acids

A

hydroxy-proline, hydroxy lysine, gamma carboxyglutamate, ornithine

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16
Q

Intracellular pathways for protein degradation

A

ubiquination, degradation in lysosomes

17
Q

Ubiquination

A

targets proteins for degradation in the proteasome

18
Q

transamination

A
  • normally in liver (less in kidney, intestine, muscle), bidirectional
  • NH2 removed from amino acid
  • NH2 added to carbon skeleton
  • NH2 transferred from nitrogen molecule to carbon skeleton or from amino acid to acceptor molecule
19
Q

Transamination reaction

A

NH2 from amino acid to alpha-ketoglutarate –>alanine – go to liver –> glutamate –> urea

20
Q

key regulated step in protein metabolism

A

NH3+CO2–> Carbamoyl phosphate via carbamoyl phosphate synthase; requires N-acetylglutamate as a cofactor

21
Q

how does ammonia

A

?