Amenorrhea

Question 1

MCC of ambiguous genitalia in a female child

Answer 1

Congenital adrenal hyperplasia

Question 2

Enzyme deficient in CAH,why is there POi inCAH

Answer 2

21 hydroxylase deficiency
17hydroxyprogesterone level is raised (>8ng/ml)

POI is due to failure of migration of germ cells from yolk sac/due to accelerated rate of depletion

Question 3

Causes of female pseudo hermaphroditism , which is MCC

Answer 3

CAH(MCC)

Adrenogenital syndrome(testosterone overproduction due to adrenocorticoid insufficiency)

11 beta hydroxylase deficiency

Mother treated with androgens/progestins

Virilizing ovarian tumor