Amacrine, RGCs, and their Functional Properties Flashcards
How many types of amacrine cell types are there?
Over 40 types.
Why are amacrine cells important?
They integrate info coming from different areas of the retina.
They modulate info before it leaves the retina.
They have the ability to process information about time (Temporal domain) Ex; how the luminance is changing over time and space.
Transient or graded responses to light.
How to categorize amacrine cells?
Can be described by the horizontal extent of their dendritic fields within the same layer. Ex: Narrow, small, medium, or wide field.
Can be described by the vertical extent of the dendritic fields. Monosaturated, bisaturated, or multi saturated (diffuse)
Rod amacrine cells: 1. What is their horizontal field extent? 2 What is their vertical field extent? 3. input 4. Output 5. Receptive field 6. NT
Major carrier of rod signal to ganglion cells.
- Narrow field.
- Bistratified.
- Input mostly from rod bipolar and other amacrine cells from sublmina B in the IPL (on)
- Output to off-center ganglion cells whose dendrites are in the sublamina A (off)
- On center, off surround.
- Glyceine, inhibitory.
A17 1. What is their horizontal field extent? 2 What is their vertical field extent? 3. input 4. Output 5. Receptive field 6. NT
Role is to increase light sensitivity at scotopic light levels. They collect signals from several thousand rod bipolar for amplification.
- Wide- makes sense so they can contact the most rods.
- Diffuse (multistratified)- makes sense. more contacts = more amplification
- Input with reciprocal Rod bipolar from sublamina B (on). Some input from dopaminergic amacrines (A18)
- Output with reciprocal rod bipolars in sublamina b (on)
- On center, no surround. No region where you can take light away and cause the cell to respond differently.
- GABA inhibitory.
A18 role
Many connections to A II amacrine cells. Thought to control IPL gap junctions through dopamine release.
Starburst amacrine cell. 1. What is their horizontal field extent? 2 What is their vertical field extent? 3. input 4. Output 5. Receptive field 6. NT
Responsive to motion. Foundation for directional tuning of motion sensitive neurons.
Occurs in mirror symmetric pairs of Ach-a and Ach-b:
Ach-a: Cell body found in INL. Dendrites stratify subliminal A (off)
Ach-b: Cell body found in GCL (weird, displaced). Dendrites stratify subliminal b (on)
- Medium with tremendous overlap in dendritic trees.
- vertical field ?
- Cone bipolars and amacrines.
- Output ?
- A is off center/on surround. B is on center/off surround
- Ach, excitatory
Interplexiform Cells (IPCs)
- Location
- Input to IPL is from?
- Output to OPL is to?
- NT
- Extends from inner to outer plexiform layer
- Input to IPL is from amacrines
- Output to OPL is to rod and cone bipolar cell bodies.
- Gaba, inhib.
How many ganglion cells are there
20 morphological different types identified
2 main types of ganglion cells. Describe them based on morphological and physiological classification
- Midget cells/P cells/Parvocellular system.
2. Parasol cells/M cells/Magnocellular system
Which type of GC makes up 70% of the total GCs in the retina?
Midget (Make up 95% of the foveal GC and 45% of peripheral GC)
How does the midget/P cell GC dendritic field and level of convergence change from the fovea, 2-6mm from fovea, and periphery?
- Projects to the parvocellular pathway of the LGN.
1. Fovea. Extremely small dendritic fields. Allows for better spatial resolution. No convergence. 1 GC connects to 1 midget bipolar, which connects to 1 cone.
2. 2-6mm from the fovea. Dendritic field becomes 10x larger. Contacts 2-3 midget bipolars, each of which is hooked up to a single cone.
3. Periphery. very large dendritic field. Contacts 2-3 midget bipolars, each of which is hooked up to 2-3 cones.
What is the dendritic field and convergence of Parasol/M GC?
Projects to the magnocellular pathway in LGN.
Parasol GC have lots of convergence. Mainly get input from aamcrine cells that are diffuse/multistriated. They receive 10-15x more input from rods compared to midget GCs.
Parasol cells are the only GCs that are active at low light levels. Therefore, they need a lot of convergence to get info.
Are midget ganglion cells active at low light levels? Are parasol cells?
Midget ganglion cells are NOT active at low light levels. Parasol cells are the only class of GC that remain active at low light levels.
Koniocellular pathway in the LGN is related to the perception of
Color vision.