Alzheimers

Question 1

What is the cause of Alzheimers?

Answer 1

exact cause is unknown

possible factors: genetics, 3 genes lead to synthesis of dysfunctional protein (amyloid) and amyloid plaque formation

Question 2

Describe the path for Alzheimers?

Answer 2

• loss of Ach and other NT’s = decline in memory, attention, and loss of other cognitive function
• development of insoluble amyloid (a neurotoxic protein) accumulates in plaques in the brain and brain vasculature leading to antipathy (disease of blood vessels)
• group of axons clump around amyloid -> degeneration -> disrupt nerve transmission

Question 3

treatment?

Answer 3

no known treatment to stop or reverse mental deterioration

Question 4

What are some medication that can be taken to manage the disease?

Answer 4

Donepezil (aricept) and/or Memantine (Namenda)

Question 5

Goal of treatment/management?

Answer 5

1. slow decline in cognitive function

2. slow progression of disease and decline in ADL’s