Alzheimers

Question 1

Meds used to tx Alzheimer’s

Answer 1

ACH inhibitors = increase ACH
1) donepezil ( aricept )
2) rivastigmine ( exelon ) - comes in a patch
3) galantamine ( razadyne)

NMDA receptor blocker
4) memantine ( Namenda )

Combo of aricept and NMDA blocker
5) ER memantine + donepezil ( namzaric )

Question 2

Donepezil

Answer 2

Aricept

Indication: mild to moderate to moderate to severe ( only one indicated for both. Rest of the ach inhibitors only for mild to moderate )

Comes ODT ( if elderly patient cant swallow this is helpful )

Question 3

Rivastigmine

Answer 3

Exelon

Comes in patch ( benefit once daily instead of bid and less nausea with patch )

Caps 1.5 mg bid with food ( nausea )

Indication: mild to moderate Alzheimer’s

Question 4

Galantamine

Answer 4

Razadyne
Indication: mild to moderate Alzheimer’s

Watch for serious skin reactions. D/C if skin rash occurs

With food ( GI upset )

Renal and hepatic impairment adjustment needed

Question 5

Cholinesterase inhibitors Side effects

Answer 5

increases ACH: SLUDGE

Question 6

Bethanechol

Answer 6

Urecholine : urinary retention

Question 7

Reversal toxic anticholinergic effects antidote

Answer 7

Physostigmine

Question 8

Tx of acute toxicity of cholinergic agent ( acetylchoinesterase poisoning)

Answer 8

Atropine

Increase heart rate for bradycardia
GI disorders
Respiration
Inhibiting salivation and secretions

0.5 - 1 mg IV q 3-5 mins max 0.04mg/kg

Question 9

Memantine

Answer 9

Namenda

NMDA receptor antagonists: blocks NMDA R and this decreases glutamate in the CNS and therefore decreases the damage in the CNS

Question 10

Donepezil + memantine

Answer 10

Namzaric

ER capsules

If you need to open capsule and sprinkle on applesauce

Question 11

Amyvid

Answer 11

Florbetapir F-18

Radioactive dx agent