Alzheimers Flashcards
Language deficit order in AD
Naming -> comprehension -> fluency
Imaging findings for Alzheimers
Posterior cortex and hippocampal atrophy
Intracranial inclusions in AD
LOW AB42, HIGH TAU
Matching dse with clinical clues
FTD
CJD
Brain tumor
Dementia with lewy bodies
Vascular Dementia
Parkinsons
NPH
A. Early Onset Seizure
B. Prominent gait disturbance w/ mild memory loss
C. Loss of joint position and vibration with Babinski sign
D. Rapid progression + rigidity + myoclonus
E. Resting tremor + bradykinesia + masked facies
F. Early appearance of parkinsonian features in association with fluctuating alertness, visual hallucinations, or delusional misidentification
G. Prominent behavioral changes with intact navigation and focal anterior-predominant atrophy on brain imaging
FTD -G
CJD - D
Brain tumor - A
Dementia with lewy bodies - F
Vascular Dementia - B
Parkinsons - E
NPH - B
Drugs approved by FDA with MOA for AD
MR DG
Memantine - NMDA receptor antagonist for MOD-SEVERE AD
Rivastigmine - Acetylcholinesterase inhibitor
Donepezil - Acetylcholinesterase inhibitor
Galantamine - Acetylcholinesterase inhibitor
Side effect of Achterase inhibitor
GI symptoms
Med for Depression in AD
SSRI (Escitalopram)
Drug for Seizure control
Levetiracetam
Drugs with protective effect on dementia if used PRIOR TO ONSET OF DISEASE but DO NOT INFLUENCE CLINICALLY SYMPTOMATIC AD
NSAID and Statin
2 subtypes of Vitamin B1 deficiency
Wernicke encephalopathy
Korsakoff syndrome
Condition: Patient is unable to recall new information despite normal immediate memory, attention span, and level of consciousness
Korsakoff syndrome
-Irreversible and profound amnestic syndrome
Condition: Malnourished patient (frequently but not necessarily alcoholic) with confusion, ataxia, and diplopia
Wernicke encephalopathy
