Alzheimer's Treatment Flashcards
1
Q
Galantamine
A
MOA: cholinesterase inhibitor and nicotinic receptor modulator
Use: Tx of Alzheimers symptoms; pt regresses in 6 months
SE: N/V
2
Q
Donepezil
A
MOA: acetylcholinesterase inhibitor
Use: Tx of Alzheimer’s symptoms; pt regresses in 6 months
Interferes with CYP450 metabolism of other compounds
3
Q
Rivastigmine
A
MOA: Acetylcholinesterase inhibitor and butyrl-cholinesterase inhibitor
Use: Tx of Alzheimers symptoms; pt regresses in 6 months
SE: N/V
4
Q
Memantine
A
MOA: NMDA glutamate receptor antagonist – enhances synaptic activity
Use: improves activities of daily living in patients with advanced disease
*effects are additive with ChE-I
