Alzheimer's Disease Flashcards
1
Q
which brain regions are affected in AD?
A
hippocampus - entorhinal cortex
cortex
basal nucelus of Meynert
2
Q
what does AD in hippocampus cause?
A
impairment of recent memory, functions and attention
3
Q
what does AD in the cortex and basal nucleus of Meynert cause?
A
failure of language skills
disorientation
impaired judgement
personality changes
4
Q
what system is the basal nucleus of Meynert part of?
A
cholinergic
5
Q
what are neuritic plaques?
A
- extracellular lesions made up of AB
6
Q
what are neurofibrillary tangles made up of?
A
- intracellular lesion
- made up micro-tubule associated protein called tau
7
Q
what is extensive synapse loss in early AD correlate to?
A
cognitive impairment
8
Q
what happens to plaques as we age?
A
increase
