Alxheimer’s Disease

Question 1

Alzheimers onest?

Answer 1

70 ish

Question 2

Pathology

Answer 2

Beta amyloid plaques and neurofibrillary tangles

Question 3

Risks?

Answer 3

Genetic - APOE APP PSEN1 PSEN2

Environmental
Inc risk: smoking, obesity, diabetes, hypertension
Dec risk: cognitive reserve, exercise and diet

Question 4

What is the clinical presentation?

Answer 4

Temporal-parietal dementia

• early visual disturbance
• language and visuospatial problems
• personality preserved until later

Question 5

Frontotemporal dementia

Answer 5

Early change in personality/behaviour
Often change in eating habits
Early dysphasia
Memory/visuospatial relatively preserved

Question 6

Dementia with Lewy Bodies

Answer 6

a synculein
Early visuospatial and executive dysfunction
Prominent fluctuation
Parkinsonism and visual hallucination common

Question 7

Vascular dementia

Answer 7

Mixed picture
Stepwise decline

Question 8

Treatment for Alzheimer’s +/- Lewy Body dementia

Answer 8

Cholinestearase inhibitors
- donepezil, rivastigimine, galantamine
- small symptomatic improvement in cognition
- no delay in institutionalisation

NMDA antagonist

Question 9

Other dementias?

Answer 9

Do nothing…