Alterations of Hematological Function

Question 1

Overview of Anemia.. what is it?

Answer 1

Abnormal decrease in RBC and or hemoglobin concentration reducing the ability of blood to carry oxygen to tissues

Question 2

Laboratory evaluation of anemia?

Answer 2

Hemoglobin (Hgb or Hb) most values come on CBC

Hematocrit (HCT) usually 3 times the hemoglobin

Question 3

Classification of Anemia by Cause

Answer 3

-inadequate erythropoiesis
(Production of RBC in bone marrow)
-loss of RBC from circulation (hemorrhage)
-hemolysis (RBC dying only live 120 days)
-dilutional Anemia

Question 4

Classification of Anemia by Cell Morphology

Answer 4

• macrocytic (larger than normal)
• normocytic (acute hemorrhage)
• microcytic (#1 cause is low iron and low hemoglobin)

Question 5

Mean cell volume (MCV)?

Answer 5

average volume of RBC’s and gives number of all RBC’s and tells if it’s normal, high, or low

Question 6

Clinical manifestation of Anemia?

Answer 6

CNS and musculoskeletal manifestations (caused by decreased oxygen delivery to CNS and skeletal muscles)

Question 7

1 symptom in Anemia

Answer 7

Fatigue and weakness

Question 8

What is Pallor?

Answer 8

Fewer RBC’s and flushed in color

Question 9

Cardiac manifestations of Anemia (seen in severe cases)

Answer 9

Caused by decreased oxygen

• chest pain (little oxygen)
• heart failure (no oxygen)

Question 10

Average amount of hemoglobin in a given volume of blood. Found of CBC

Answer 10

Hemoglobin (Hgb)

Question 11

% of a given volume of blood that is comprised of RBC’s

Answer 11

Hematocrit (Hct)

Question 12

Average mass of hemoglobin per red blood cell in a sample of blood.

Answer 12

Mean cell hemoglobin (MCH)

Question 13

Iron is stored as what in the liver and bone marrow?

Answer 13

Ferritin

Question 14

Jaundice occurs from what?

Answer 14

Unconjugated bilirubin

Question 15

When the cell lyses or dies it produces…?

Answer 15

LDH lactate dehydrogenase