Alterations in Neural Function Flashcards

1
Q

what is increased intracranial pressure? Causes? Symptoms?

A

-increase in pressure in brain

common causes:
-inflammation (infection, inflammatory response to injury)
-mass (tumor)
-bleeding (hemorrhagic stroke)
-aneurysm (takes up space, may bleed)

common symptoms:
-headache
-blurred vision
-altered LOC
-NV
-behavioral changes
-weakness
-difficulty speaking
-seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what is traumatic brain injury? what are the types?

A

-Injury to brain from trauma
-Leading cause of death and disability in U.S. for persons under 24.
- Most r/t transportation-related accidents, falls, firearms & sports

Types of TBI
Focal injuries: (coup) localized to site of impact.

Polar injuries: (coup contrecoup) d/t acceleration-deceleration movement of brain within skull, resulting in double injury (usually opposite focal injury).

Diffuse injury: D/t movement of brain within skull, resulting in widespread axonal injury.

Concussion:
Mild TBI; most common injury of military personnel & athletes
-Alteration in or loss of consciousness (< 30 minutes)
-No evidence of brain damage on CT
-HA, nausea, vomiting, dizziness, fatigue, blurred vision, cognitive & emotional disturbances

Contusion: CT or MRI reveals area of brain tissue damage (necrosis, laceration, bruising)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is an intracranial hematoma? what can cause the injury? etiology?

A

Localized collection of blood within the cranium.
Break in blood vessel in cranium causes hemorrhage and inflammation.
Expands slowly or rapidly; compresses brain & causes increased ICP

Mechanisms of injury:
-blunt (closed, non-penetrating)
-penetrating (open)
-compression

Types of intracranial bleeds: epidural, subdural, or intracerebral.

Etiologies: MVA, falls, violence, sports injuries, drugs, traumatic birth injury.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is an epidural hematoma? CM? Diagnosis? Tx?

A

Collection of blood between dura & skull.

Usually arterial injury thus rapid onset of symptoms.

Associated with skull fracture; often temporal bone.

Manifestations: primary injury is minor, may suffer only brief period of disturbed consciousness followed by period of normal cognition (lucid interval), then LOC rapidly deteriorates

Diagnosis: CT scan

Treatment: surgery to remove hematoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is a subdural hematoma? Dx? Tx?

A

-Collection of blood between dura & outer layer of arachnoid membrane.
-Involves bridging veins, thus symptom onset slower.
-Chronic prone to re-bleeding.

Acute: symptomatic within 24-72 hrs.

Subacute: increased ICP (HA, N/V, blurred vision) 2-10 days later

Diagnosis: CT, MRI

Treatment: remove tissue and clot

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is a subarachnoid hemorrhage?

A

-Collection of blood between arachnoid membrane and pia mater.
-D/t rupture of bridging veins that pass through subarachnoid space.
-More commonly associated with rupture of cerebral aneurysms or arteriovenous malformations; arterial in origin.
-Blood spreads throughout CSF, causing meningeal irritation, hydrocephalus, headache, vasospasms, ischemia.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what is secondary injury?

A

-Initiated by TBI.
-Result from ischemia, increased ICP & altered vascular regulation.
-Ischemic & hypoxic events, edema & other processes that lead to IICP and may affect pt outcomes to a greater extent than the primary injury.
-Ruptured vessels may re-bleed or spasm, and CSF drainage can become clogged.
-Concomitant trauma may complicate brain injury.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what is cerebrovascular disease and stroke? what are the types?

A

Sudden onset of neurologic dysfunction d/t cardiovascular disease
-Abnormality in cerebral perfusion results in localized area of brain infarction.
-Third leading cause of death in U.S.
-Most common form of stroke is ischemic.

Types:
ISCHEMIC
-Thrombotic: atherosclerosis,
-Embolic: A-fib, valve disease, hypercoagulable states

HEMORRHAGIC
-structural anomalies
-hypertension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what are transient ischemic attacks? Cause? Warning signs? Tx?

A

Mimic a stroke for few secs to few hrs without permanent damage.
-Caused by temporary interference in cerebral blood flow.

Important warning sign for possible stroke.
-Neurologic symptoms can last mins. up to 24 hrs
-Symptoms resolve without lasting neurologic dysfunction

Tx: daily ASA; carotid endarterectomy, angioplasty

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is ischemic stroke?

A

-Sudden occlusion of a cerebral artery secondary to thrombus (arteriosclerosis) or embolus (atrial fibrillation).
-O2 to neurons is reduced, Na+ pump & neurotransmitters fail leading to cerebral edema, vasospasm & reduced cerebral perfusion.
-If anoxia lasts longer than 10 minutes = irreversible damage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is hemorrhagic stroke?

A

-Occurs with long standing HTN
-Large hemorrhage results in significant ICP
-Degree of secondary injury & associated morbidity & mortality much higher in hemorrhagic stroke than ischemic stroke

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is stroke sequelae?

A

Motor and Sensory Deficits
Motor: Flaccidity/paralysis; function recovery occurs with onset of spasticity
-Contralateral to side of brain where stroke occurred
Sensory: Same areas as motor, contralateral field blindness

Language Deficits
-Aphasia d/t cerebral damage; can involve all language modalities
-Broca aphasia (verbal motor/expressive): Poor articulation & sparse vocabulary
-Wernicke aphasia (sensory, acoustic, receptive): Impaired auditory comprehension and speech that is fluent but does not make sense

Cognitive Deficits
-Area of brain affected dictates presence & severity.
-Impairment in language, spatial relationship skills, short-term memory, concentration, reasoning & judgment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what is a cerebral aneurysm?

A

-weakened vessel that leads to dilation & ballooning
-Congenital defect of layer of artery weakens to arterial pressure, allowing dilated portion to fill with blood & eventually burst causing subarachnoid hemorrhage.
-Most found in Circle of Willis.
-Typical presentation is severe HA.
-HTN, acute ETOH intoxication, & recreational drug use implicated.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what is an arteriovenous malformation?

A

-Tangle of enlarged vessels that can burst
-Pts. typically present with seizure & neurological dysfunction.
-May enlarge & compress adjacent structures or rupture.
-D/t high vascular pressure AVM’s are vulnerable to hemorrhage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is meningitis? CM?

A

Bacteria reach CNS via blood stream or extension from cranial structures like ears & sinuses.

Viral: Self-limiting with complete recovery (herpes).

Bacterial: Leaves residual effects (Neisseria meningitis, streptococcus, haemophilus).
- Often follows upper respiratory infection.
-Pathogen crosses BBB & migrates in CNS causing inflammation with increased CSF which increases ICP.

Manifestations; Fever, vomiting, nuchal rigidity (neck stiffness), signs of IICP, septic emboli

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what is encephalitis? CM?

A

-Inflammation of brain commonly caused by West Nile virus, western equine encephalitis, and herpes simplex
-Transfer usually by mosquito from animals to humans.
-Causes inflammation & lysis of cells.

Manifestations: cerebral edema, headache, fever, confusion, convulsions, weakness and rash.

17
Q

what is brain abscess?

A

Localized collection of pus within brain parenchyma.
-Presents as space-occupying lesion with changes in LOC & typically signs of infectious etiology.
-Associated with penetrating wounds, mastoiditis, sinusitis, or blood-borne dissemination from a distant site.
-Organisms include: streptococcus, staphylococci, and anaerobes.

18
Q

what is seizure disorder/epilepsy? etiology? What are the types?

A

Abnormal or excessive cortical electrical discharges manifested by disturbances of skeletal motor function, sensation, autonomic function, behavior, or consciousness.
-Neurons become abnormally hyperactive & hypersensitive to changes in their environment.
-Epilepsy or seizure disorder refers to recurrent seizures

Etiologies: Genetic, acquired from pathologic conditions, head injury, infections, space-occupying lesions, metabolic—electrolyte imbalance, hypoxia, acidosis, renal failure, drugs

Non synchronized neuronal activity, with groups of neurons inhibited & excited during transfer of info between different brain areas.
Type depends on location & pattern of spread.

Generalized seizures: Involve entire brain from onset of seizure.

Focal/Partial seizures: Abnormal electrical activity is restricted to one brain hemisphere.

Status epilepticus: Continuing series of seizures without a period of recovery between episodes & can be life-threatening.

19
Q

what is cerebral palsy? etiology?

A

-Common disorder of childhood.
-Damage to motor control centers of brain.
-Classified on basis of neurologic signs and symptoms.
-Types include: spasticity (hypertonia), dyskinesia (involuntary movement and fine motor coordination), ataxic (gait disturbances), hypotonic (low muscle tone) and mixed.

Etiologies: Prenatal infections, birth trauma, exposure to poisons, and reduced oxygen supply to the brain.

20
Q

what is hydrocephalus? what are the types?

A

Abnormal accumulation of CSF in cerebral ventricular system associated with congenital neural tube defects. May occur in adults from lesions or hemorrhage.

Three Types:
-Normal pressure: d/t increase in volume of CSF without change in pressure
-Obstructive: d/t obstruction to flow of CSF
-Communicating: abnormal absorption of fluid.

21
Q

what is multiple sclerosis? etiology? patho? CM? tx?

A

Slowly progressive demyelinating disease of CNS

Etiology: Unknown. Autoimmune & environmental factors suspected.

Patho: Destruction of myelin sheath interrupts conduction of nerve impulses.
-Causes inflammation & sclerosis of myelin sheaths
-Demyelization can occur throughout CNS, often affects optic & oculomotor nerves & spinal nerve tracts.

Manifestations: double/blurred vision, weakness, poor coordination, sensory deficits; bowel & bladder control loss; memory impairment.
-Exacerbations/remissions; heat, infxn trauma, stress.

TX: Steroids for acute exacerbations. Immune-modifying rxs may slow symptom progression

22
Q

what is spina bifida? dx? CM? tx?

A

Incomplete closure of neural tube

Spina bifida occulta: Not visible

Spina bifida cystica: External protrusion of saclike structure

Dx: prenatally (ultrasound and α-fetoprotein testing)

Clinical manifestations: saclike cyst filled with CSF, spinal cord, and/or meninges; permanent neurologic damage resulting in motor weakness or paralysis & sensory deficit below level of spinal defect

Tx: surgery, C-section, folic acid before & during pregnancy

23
Q

what is amyotrophic lateral sclerosis (Lou Gehrig’s Disease)? etiology? CM? dx/ tx?

A

Degenerative dse of upper & lower motor neurons of cerebral cortex, brain stem & spinal cord resulting in total paralysis. Demyelination occurs.
-More common in men, between 40-60 years.
-Fatal in 3-5 yrs.

Etiology: idiopathic, viral infections, metabolic disorders, autoimmune.

Clinical manifestations: weakness, atrophy, cramps, stiffness, irregular twitching of muscles, hyperreflexia in weak, atrophied extremity

Dx: Based on clinical S/S, nerve conduction studies, MRI, & labs

Tx: comfort measures, no cure

24
Q

what is spinal cord injury? What are the types?

A

-Consequence of trauma-falls, MVA, sports injury.
-Compression, transection, or contusion. Further damage from hemorrhage, edema & ischemia.
-Types of injury: hyperflexion, hyperextension, compression.

TYPES:
1. Spinal Shock
-Immediately follows injury: temporary loss of reflexes & muscle flaccidity below level of injury.
-Lasts 2 days to several mos.
-Associated with hypotension & bradycardia.
-Resolves when reflexes return & flaccidity replaced by spasticity
2. Neurogenic Shock
-Peripheral vasodilatation after injury
-Hypotension & circulatory collapse can occur; high cord injuries affect respiratory muscles, leading to ventilatory failure.
3. Autonomic Dysreflexia
-Occurs with injury at or above T6
-Abnormal, overreaction of the ANS to stimulation
-Acute reflexive response to sympathetic activation below level of injury.
-Manifestations: HTN, HA, bradycardia, flushing above the level of injury & clammy skin below level of injury.

25
Q

what is Guillain-Barre syndrome? etiology? patho? CM?

A

Inflammatory demyelinating disease of peripheral nervous system or a lower motor neuron disorder.
-Also known as Acute Idiopathic Polyneuropathy
Etiology: Idiopathic, often follows viral infection. May be auto immune.
Pathogenesis: Antibody formation damages peripheral nerve myelin, impulses are slowed.
Manifestations: Sudden ascending muscle weakness beginning in lower extremities & moving upward.
-Spontaneous recovery usually occurs
-Remyelination occurs in descending order over periods of months.

26
Q

what is Bell’s Palsy? etiology? CM?

A

Paralysis of muscles on one side of face, idiopathic

Etiology: virus, self-limiting.

Clinical manifestations: Develop rapidly over 24-48 hrs., unilateral facial weakness, droop & diminished eye blink & lacrimation (tears) & hyperacusis (sensitivity to sounds)
-May last days to wks.