alports syndrome Flashcards
1
Q
inheritance pattern in Alports
A
X linked dominant
2
Q
pathophysiology
A
gene that codes for type IV collagen resulting in abnormal GBM
3
Q
why can Alports lead to failing renal transplant
A
due to anti GBM antibodies leading to goodpasture’s like picture
4
Q
features of Alport
A
microscopic haematuria
progressive renal failure
bilateral sensorineural deafness
lenticonus
retinitis pigmentosa
5
Q
features of renal biopsy
A
splitting of lamina densa seen on electron microscopy
