Alpha blockers

Question 1

What do Alpha I agonist do in the heart

Answer 1

Cause increased contractility

Question 2

What do Alpha 1 agonists do on the blood vessels

Answer 2

Vasoconstriction

Question 3

What do alpha 1 agonists do on the kidneys

Answer 3

Vasoconstriction

Question 4

What do alpha 1 agonists do to thrombocytes

Answer 4

Aggregation

Question 5

What do alpha 1 agonists do to adipocytes

Answer 5

Inhibit lipolysis

Question 6

Agonist affinity for alpha receptors

Answer 6

Norepinephrine> epinephrine&raquo_space; isoprenaline

Question 7

Why does blood pressure have a tendancy to increase with age

Answer 7

Because the number of Alpha i receptors in vascular smooth muscle increases. Activation of these receptors causes vasoconstriction

Question 8

Describe the location of alpha receptors on neuromuscular terminals in VSM

Answer 8

Pre-synaptic alpha 2 receptors.

Post synaptic alpha 1 receptors

Question 9

Name one alpha 1 antagonist

Answer 9

Doxazosin

Question 10

Describe PD of doxazosin

Answer 10

Reversible alpha blockade (a1»>a2).
Vasodilator
Reduces prostate symptoms

Question 11

Indications for use of an alpha blocker

Answer 11

Essential hypertension (combonation therapy)
BPH

Question 12

Side effects of alpha blockers

Answer 12

Orthostatic hypotension
Dizziness
Lassitude
Nasal stuffiness
Dry mouth
Urinary incontinece (females)