Alpha-Adrenergic Receptor ANTagonists

Question 1

Non-selective alpha-receptor ANTagonists: Playas play

Answer 1

PHENOXYBENZAMINE (irreversible)

PHENTOLAMINE (reversible)

Question 2

Non-selective alpha-receptor ANTagonists-CV

Answer 2

• inhibit vasCONSTRICTION (decreases bp)
• INCREASED inotropy and chronotropy due to blockade of pre-synaptic alpha TWO receptor
• reflex INCREASE in NE release in response to hypOtension, unmasks vasoDILATORY effect of EPI

Question 3

Non-selective alpha-receptor ANTagonists-Therapeutic

Answer 3

hypErtension associated wit perioperative treatment of pheochromocytoma, (test for pheochromocytoma), dermal necrosis, (and sloughing with vasoconstrictor extravasation

Question 4

Non-selective alpha-receptor ANTagonists-Toxicity

Answer 4

• prolonged hypOtension
• reflex tachycardia
• nasal congestion

Question 5

Non-selective alpha-receptor ANTagonists-Ci

Answer 5

coronary artery disease (CAD)

Question 6

Selective alpha ONE receptor BLOCKERS-Playas playyy

Answer 6

PRAZOSIN
DOXAZOSIN
TERAZOSIN

(PDT-ZOSIN), I was zosin’ on the D in PT

Question 7

Selective alpha ONE receptor BLOCKERS-CV

Answer 7

• inhibit vasoconstriction

- LESS cardiac stimulation than non-selective alpha blockers due to preservation of alpha TWO adrenergic function

Question 8

Selective alpha ONE receptor BLOCKERS-Therapeutic Use

Answer 8

HTN, benign prostatic hyperplasia

Question 9

Selective alpha ONE receptor BLOCKERS-Toxicity

Answer 9

syncope, orthostatic hypOtension