Alpha Adrenergic Antagonists Flashcards
Phentolamine has a duration of action of ___________ (15-50hrs/1-2hrs)
1-2hrs
Phentolamine is used for the short term management of _________________
Pheochromocytoma
Phentolamine is a ___________ (nonselective competetive alpha blocker/selective competetive alpha 1 blocker)
nonselective competetive alpha blocker
Phentolamine produces ____________ (postural hypotension/bronchoconstriction) and epinephrine reversal.
postural hypotension
___________ (phentolamine/prazosin) is used to treat dermal necrosis following extravasation of epinephrine.
Phentolamine
Prazosin is prototype of _______________ (nonselective competetive alpha blocker/selective competetive alpha 1 blocker)
selective competetive alpha 1 blocker
___________ (prazosin/phenylephrine) reduces peripheral resistance and blood pressure.
Prazosin
Prazosin has a _______ (short/long) duration of action
long (10hrs)
Prazosin has a ________ (slow/rapid) onset
slow (2-4hrs)
ROA of Prazosin is _______ (oral/IV)
oral
Prazosin is sold under the brand name _________
Minipress
Phentolamine is sold under the brand name __________
Regitine
ROA of phentolamine is ________ (oral/IV)
IV
Tamsulosin and Silodosin have greater efficacy for treatment of ____________
Benign Prostatic Hyperplasia
Tamsulosin has selective action at ____________ (alpha 1A/alpha 1B) receptors on the bladder and prostate
alpha 1A receptors
Phenoxybenzamine has a ________(short/long) duration of action because it binds covalently
long (15-50hr) about 24hrs
Inactive products of _________ (Doxazosin/Alfuzosin) are excreted in feces.
Doxazosin
Out of all the drugs, ___________ is the longest acting. (prazosin/tamsulosin/alfuzosin/doxazosin)
Doxazosin
Phenoxybenzamine is a ____________ (noncompetetive/competetive) irreversible antagonist with some selectivity for ________ (alpha 1/alpha 2) receptors although it works at both.
noncompetetive
alpha 1
Phenoxybenzamine is sold under the brand name __________
Dibenzyline
_____________ (Prazosin/Phenoxybenzamine) is sometimes useful for the treatment for frostbite and Raynaud disease.
Phenoxybenzamine
Phenoxybenzamine is no longer used to treat hypertension because it blocks ____________ (presynaptic inhibitory alpha 2/alpha 1) receptors in the heart leading to an increased cardiac output.
presynaptic inhibitory alpha 2 receptors
Reflex tachycardia is one of the adverse effect of ____________ and ____________ (phenoxybenzamine/prazosin/tamsulosin/phentolamine)
phenoxybenzamine and phentolamine
___________ (alfuzosin/phentolamine) is used for the treatment of BPH
Alfuzosin
______________ is contraindicated in coronary artery disease because it triggers arrhythmias and anginal pain
Phenoxybenzamine
All alpha adrenergic blockers reverse the alpha agonist actions of epinephrine. This is known as ___________
Epinephrine reversal
Alpha 1B receptors are found on ___________ (blood vessels/prostate/bladder
blood vessels
Blockade of alpha 1A receptors __________ (increases/decrease) the tone of smooth muscle of the bladder and prostate.
decreases
_____________ (Phentolamine/Tamsulosin) improves urine flow in patients of BPH
Tamsulosin
_____________ (Prazosin/Phenoxybenzamine is useful in the chronic managment of inoperable tumors of adrenal glands
Phenoxybenzamine
FIrst dose of _________ may produce an exaggerated orthostatic hypotensive response that can result in syncope.
alpha 1 blockers
___________ are not used as monotherapy for the treatment of hypertension because of low outcomes.
alpha 1 blockers
___________ (Phentolamine/Phenoxybenzamine) may inhibit ejaculation
Phenoxybenzamine
_____________ should be used with caution in patients wiith cardivascular or cerebrovascular disease
Phenoxybenzamine
What are some adverse effects of phenoxybenzamine?
Postural hypotension Nausea Vomiting Nasal stuffiness Reflex tachycardia Inhibit ejaculation
______________ have been used as an alternative to surgery in patients with BPH
Alpha 1 blockers
What are some adverse effects of alpha 1 blockers?
Dizziness Lack of energy Nasal congestion Headache Drowsiness Orthostatic hypotension Inhibition of ejaculation Retrograde ejaculation Floppy iris syndrome (during intraoperative eye surgery)
An additive _________ (hypertensive/antihypertnesive) effect occurs when alpha 1 blockers are given with vasodilators such as nitrates or PDE-5 inhibitors (sildenafil)
Antihypertensive
__________ is an example of selective competetive alpha 2 blocker.
Yohimbine
Yohimbine works at the level of the CNS to _________ (increase/decrease) the sympathetic outflow to the periphery.
Increase
_____________ is containdicated in cardiovascular disease, psychiatric conditions and renal dysfunction
Yohimbine
___________ was used as a sexual stimulant and in the treatment of erectile dysfunction.
Yohimbine
Alfuzosin is sold under the brand name of __________
Uroxatral
Doxazosin is sold under the brand name of _________
Cardura
Tamsulosin is sold under the brand name of ________
Flomax
Terazosin is sold under the brand name of __________
Hytrin
Yohimbine is sold under the brand name of ________
Yocon
