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Pharmacology - Foundation Module > Alpha Adrenergic Antagonists > Flashcards

Alpha Adrenergic Antagonists Flashcards

1
Q

Phentolamine has a duration of action of ___________ (15-50hrs/1-2hrs)

A

1-2hrs

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2
Q

Phentolamine is used for the short term management of _________________

A

Pheochromocytoma

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3
Q

Phentolamine is a ___________ (nonselective competetive alpha blocker/selective competetive alpha 1 blocker)

A

nonselective competetive alpha blocker

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4
Q

Phentolamine produces ____________ (postural hypotension/bronchoconstriction) and epinephrine reversal.

A

postural hypotension

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5
Q

___________ (phentolamine/prazosin) is used to treat dermal necrosis following extravasation of epinephrine.

A

Phentolamine

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6
Q

Prazosin is prototype of _______________ (nonselective competetive alpha blocker/selective competetive alpha 1 blocker)

A

selective competetive alpha 1 blocker

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7
Q

___________ (prazosin/phenylephrine) reduces peripheral resistance and blood pressure.

A

Prazosin

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8
Q

Prazosin has a _______ (short/long) duration of action

A

long (10hrs)

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9
Q

Prazosin has a ________ (slow/rapid) onset

A

slow (2-4hrs)

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10
Q

ROA of Prazosin is _______ (oral/IV)

A

oral

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11
Q

Prazosin is sold under the brand name _________

A

Minipress

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12
Q

Phentolamine is sold under the brand name __________

A

Regitine

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13
Q

ROA of phentolamine is ________ (oral/IV)

A

IV

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14
Q

Tamsulosin and Silodosin have greater efficacy for treatment of ____________

A

Benign Prostatic Hyperplasia

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15
Q

Tamsulosin has selective action at ____________ (alpha 1A/alpha 1B) receptors on the bladder and prostate

A

alpha 1A receptors

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16
Q

Phenoxybenzamine has a ________(short/long) duration of action because it binds covalently

A

long (15-50hr) about 24hrs

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17
Q

Inactive products of _________ (Doxazosin/Alfuzosin) are excreted in feces.

A

Doxazosin

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18
Q

Out of all the drugs, ___________ is the longest acting. (prazosin/tamsulosin/alfuzosin/doxazosin)

A

Doxazosin

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19
Q

Phenoxybenzamine is a ____________ (noncompetetive/competetive) irreversible antagonist with some selectivity for ________ (alpha 1/alpha 2) receptors although it works at both.

A

noncompetetive

alpha 1

20
Q

Phenoxybenzamine is sold under the brand name __________

A

Dibenzyline

21
Q

_____________ (Prazosin/Phenoxybenzamine) is sometimes useful for the treatment for frostbite and Raynaud disease.

A

Phenoxybenzamine

22
Q

Phenoxybenzamine is no longer used to treat hypertension because it blocks ____________ (presynaptic inhibitory alpha 2/alpha 1) receptors in the heart leading to an increased cardiac output.

A

presynaptic inhibitory alpha 2 receptors

23
Q

Reflex tachycardia is one of the adverse effect of ____________ and ____________ (phenoxybenzamine/prazosin/tamsulosin/phentolamine)

A

phenoxybenzamine and phentolamine

24
Q

___________ (alfuzosin/phentolamine) is used for the treatment of BPH

A

Alfuzosin

25
Q

______________ is contraindicated in coronary artery disease because it triggers arrhythmias and anginal pain

A

Phenoxybenzamine

26
Q

All alpha adrenergic blockers reverse the alpha agonist actions of epinephrine. This is known as ___________

A

Epinephrine reversal

27
Q

Alpha 1B receptors are found on ___________ (blood vessels/prostate/bladder

A

blood vessels

28
Q

Blockade of alpha 1A receptors __________ (increases/decrease) the tone of smooth muscle of the bladder and prostate.

A

decreases

29
Q

_____________ (Phentolamine/Tamsulosin) improves urine flow in patients of BPH

A

Tamsulosin

30
Q

_____________ (Prazosin/Phenoxybenzamine is useful in the chronic managment of inoperable tumors of adrenal glands

A

Phenoxybenzamine

31
Q

FIrst dose of _________ may produce an exaggerated orthostatic hypotensive response that can result in syncope.

A

alpha 1 blockers

32
Q

___________ are not used as monotherapy for the treatment of hypertension because of low outcomes.

A

alpha 1 blockers

33
Q

___________ (Phentolamine/Phenoxybenzamine) may inhibit ejaculation

A

Phenoxybenzamine

34
Q

_____________ should be used with caution in patients wiith cardivascular or cerebrovascular disease

A

Phenoxybenzamine

35
Q

What are some adverse effects of phenoxybenzamine?

A 
Postural hypotension
Nausea
Vomiting
Nasal stuffiness
Reflex tachycardia
Inhibit ejaculation
36
Q

______________ have been used as an alternative to surgery in patients with BPH

A

Alpha 1 blockers

37
Q

What are some adverse effects of alpha 1 blockers?

A 
Dizziness
Lack of energy
Nasal congestion
Headache
Drowsiness
Orthostatic hypotension
Inhibition of ejaculation
Retrograde ejaculation
Floppy iris syndrome (during intraoperative eye surgery)
38
Q

An additive _________ (hypertensive/antihypertnesive) effect occurs when alpha 1 blockers are given with vasodilators such as nitrates or PDE-5 inhibitors (sildenafil)

A

Antihypertensive

39
Q

__________ is an example of selective competetive alpha 2 blocker.

A

Yohimbine

40
Q

Yohimbine works at the level of the CNS to _________ (increase/decrease) the sympathetic outflow to the periphery.

A

Increase

41
Q

_____________ is containdicated in cardiovascular disease, psychiatric conditions and renal dysfunction

A

Yohimbine

42
Q

___________ was used as a sexual stimulant and in the treatment of erectile dysfunction.

A

Yohimbine

43
Q

Alfuzosin is sold under the brand name of __________

A

Uroxatral

44
Q

Doxazosin is sold under the brand name of _________

A

Cardura

45
Q

Tamsulosin is sold under the brand name of ________

A

Flomax

46
Q

Terazosin is sold under the brand name of __________

A

Hytrin

47
Q

Yohimbine is sold under the brand name of ________

A

Yocon

Pharmacology - Foundation Module (3 decks)

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