Allosteric Interaction

Question 1

______________________ occur when specific molecules _________________ and modulate activity.

Answer 1

Allosteric interaction

Bind a protein

Question 2

________________bind their _____________and promote conformational change that modulates that _________________ of the protein.

Answer 2

Allosteric effectors

Target proteins

Functional properties

Question 3

______________ allosteric effectors bind at the ____________________.

Answer 3

Homotropic

active site

Question 4

________________ effectors bind at __________________ on the protein.

Answer 4

Heterotropic

other sites

Question 5

Ex. Hemoglobin.

Oxygen is a _______________________, its binding to heme ______________ binding affinity of oxygen to other hemes in tetramer.

Answer 5

Positive homotropic effector

Increases

Question 6

Hemoglobin ex.

H+, CO2, and _______________________ produced in glycolysis are ___________________, binding of one or more of these effectors decrease the binding affinity of oxygen to hemoglobin.

Answer 6

2,3-bisphosphoglycerate (2,3-BPG)

Negative heterotropic effectors