Allergy and Immunology

Question 1

Angioedema associated with what class of medications?

Answer 1

ACE-inhibitors

Question 2

Hereditary form of angioedema caused by deficiency of what enzyme? What test do you order?

Answer 2

C1 esterase inhibitor deficiency

Order C2 and C4, will see low levels

Question 3

Treatment for acute angioedema?

Answer 3

FFP

Question 4

Treatment for chronic angioedema?

Answer 4

Ecallantide or androgens (Danazol, Stanazol)

Question 5

Recurrent episodes of sinopulmonary infections along with sprue-like abdominal symptoms. With low total IgG levels. Diagnosis?

Answer 5

Common Variable Immunodeficiency (CVID)

Question 6

Treatment for Common Variable Immunodeficiency?

Answer 6

IV immunoglobulins

Question 7

Male child with recurrent sinopulmonary infections. Lymph nodes, adenoids, spleen size diminished. B cells and immunoglobulins missing. Diagnosis?

Answer 7

X-linked Agammaglobulinemia

Question 8

Treatment for X-linked Agammaglobulinemia?

Answer 8

IV immunoglobulins

Question 9

Most common primary immunodeficiency?

Answer 9

IgA deficiency

Question 10

Treatment for IgA deficiency?

Answer 10

Treat infections as they come. IV immunoglobulin doesn’t have much IgA in it so it doesn’t help.

Question 11

Recurrent skin infections caused by Staph. Suspect what disorder?

Answer 11

Hyper IgE syndrome