allergy Flashcards
what is allergy
define atopy
specifically altered reactivity of the organism
allergen specific, reproducible immune mediated hypersensitivity where allergens are foreign substances that are usually not harmful
Atopy
A personal and/or familial tendency to produce IgE antibodies in response to ordinary exposures to potential allergens, usually proteins.
Strongly associated with asthma, rhinitis and conjunctivitis, eczema and food allergy.
define allergen
substance stimulating th epridcution of IgE a cellular response
usually a protein
define sensitisation
production of IgE ABs after repeated exposure to an allergen
no symptoms suggesting immediate onset allergy
atopy define
tendency to produce IgE ABS in response to ordinary exposure to potential allergens
how to assess suspected allergy
context of reaction
presenting Sx
food considerations
mainfestation
DDx
IgE mediated 0 skin prick or blood tests
not IgE mediated -> elimination diet
pollen food syndrome
their react to raw fresh fruit vegetables
lcoalised to the contact region ie mouth lips tongue w itch and welling
stomach acid denatures these pollen
pollen food syndrome
their react to raw fresh fruit vegetables
lcoalised to the contact region ie mouth lips tongue w itch and welling
stomach acid denatures these pollen
they do not become anaphylactic
how to increase tolerance
cows milk - forms bonds to reduce availability and allergenicity
egg white when cooked
peanut if dry roasted
fish -> canned tuna and salmon reduces allergy levels
what is cows milk protein allergu
reproducible adverse reaction to one or more milk proteins mediated by one or more of immune mechanisms
presentatio of cows milk protein
present before 12 months
non IgE -> rectal bleeding only to FPIES
IgE -> urticaria to anaphylaxis
earlier tolerance to baked milk
Food protein enterocolitis syndrome
non-IgE mediated food hypersensitivity
present Sx delayed 1-3 hours after contact prfuse repetitive comiting leading to shick occasionally watery diarrhoea pallor and shcok
Diagnosis frequently missed
- …..
Food protein enterocolitis syndrome
non-IgE mediated food hypersensitivity
present Sx delayed 1-3 hours after contact prfuse repetitive comiting leading to shick occasionally watery diarrhoea pallor and shcok
Diagnosis frequently missed
- …..
rhinitis
inflammatory disorder of the nasal mucosa initialted by an allergic immune response
Antihistamines classification
first generation
- travel BBB more than second
second generation
define mastocytosis
exaggerated reaction in the absence of allergy
