Allergies

Question 1

TQ
Describe the categories of asthma.
-Intermittent:
-Mild persistent:
-Moderate persistent:
-Severe persistent:

Answer 1

• Intermittent: 2 days/wk or 2 nights/month
• Mild persistent: >2 days/wk or >2 nights/month
• Moderate persistent: everyday, but not all day
• Severe persistent: constant symptoms

Question 2

What is the FEV1 associated with each category of asthma?

Answer 2

• Intermittent = 100%
• Mild persistent = 80%
• Moderate persistent = 60%
• Severe persistent =

Question 3

What Rx do you give for asthma rescue?

Answer 3

Beta-2 agonist

albuterol

Question 4

What Rx would you give for control/maintenance?

Answer 4

• Anticholinergics (ipratropium for inpatient)

- Inhaled corticosteroids (start low)

Question 5

What are some mast cell stabilizers used in asthma tx?

Answer 5

Cromolyn

Nedocromil

Question 6

What is the methylxanthine used in tx of asthma?

Answer 6

Theophylline

Question 7

Explain the Asthma Action Plan in terms of peak flow and the correlating zone.

Answer 7

Peak flow:
≥80%=GREEN
60-80%=YELLOW

Question 8

50% of pts with eczema develop ______.

50-75% develop ________ ________.

MOA?

Answer 8

50% of pts with eczema develop ASTHMA.

50-75% develop ALLERGIC RHINITIS.

MOA: Atopy!

Question 9

What is the atopic march?

Answer 9

• Atopy: personal and/or familial propensity to produce IgE Abs and sensitization in response to environmental triggers
• Describes progression of atopic disorders from atopic derm in infants to AR and RAD in children

Question 10

TQ

What is the MOA of the atopic march?

Answer 10

Early barrier dysfunction (atopic dermatitis – itch before rash!) ››
Epicutaneous sensitization ››
Th2 response with increased IgE and increased IL-13 ››
Asthma, atopy

Question 11

• Inflammatory condition of nasal mucosal membranes
• Allergens provoke allergic response in sensitized individuals
• 80% with have asthma
• Even without asthma, pts have increased lower airway reactivity
• Can precede asthma in allergic march or be an endpoint

Answer 11

Allergic rhinitis

Question 12

Atopic dermatitis and ____ _______ commonly coexist.

Mediated by which Ig?

Answer 12

Atopic dermatitis and FOOD ALLERGY commonly coexist.

Mediated by IgE***