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Biochem Final > All regulated steps > Flashcards

All regulated steps Flashcards

1
Q

PFK1

A

Glycolysis
F6P»F1,6BP
requires ATP

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2
Q

Hexokinase

A

Glycolysis
glucose»G6P
requires ATP

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3
Q

Phosphoglycerate Kinase

A

Glycolysis
1,3-BPglycerate»3-phosphoglycerate
makes ATP

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4
Q

Pyruvate Kinase

A

Glycolysis
PEP»pyruvate
makes ATP

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5
Q

GAP Dehydrogenase

A

**Not a regulated step
Glycolysis
makes NADH

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6
Q

Pyruvate Carboxylase

A

Gluconeogenesis
pyruvate»OAA
requires ATP

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7
Q

PEP carboxylase

A

Gluconeogenesis
OAA»PEP
requires ATP

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8
Q

F1,6-bisphosphatase

A

Gluconeogenesis
F1,6BP»F6P
requires ATP

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9
Q

G6-phosphatase

A

Gluconeogenesis
G6P»Glucose
requires ATP

Glycogen Degradation
-same reaction

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10
Q

PDH complex

A

pyruvate»acetyl-CoA + CO2 + NADH

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11
Q

Isocitrate dehydrogenase

A

CAC

isocitrate»alpha-KG + CO2 + NADH

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12
Q

alpha-KGDH

A

CAC

alpha-KG»succinyl-CoA + CO2 + NADH

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13
Q

PDH Kinase

A

regulates PDH complex via phosphorylation

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14
Q

Glycogen Phosphorylase

A

Glycogen degradation

  • releases G1P from glycogen
  • *active when phosphorylated
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15
Q

Glycogen Synthase

A

Glycogen synthesis

takes glucose from UDP-glucose to alpha(1,4) glycosidic bonds (non-reducing ends)

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16
Q

G6PD

A

PPP

G6P»6-phosphoglucolactone + NADPH

17
Q

CPT 1

A

FA degradation
- transport of FA into mitochondria
acyl-CoA + carnitine» acyl-Canitine

18
Q

HMG-CoA Lyase

A

Ketone Bodies Synthesis

HMG-CoA»Acetoacetate

19
Q

Acetyl-CoA Carboxylase

A

FA synthesis

acetyl-CoA»malonyl-CoA

20
Q

HM-CoA Reductase

A

Cholesterol synthesis

HMG-CoA + 2 NADPH&raquo_space; Mevalonic acid

21
Q

Phosphocholine cytidyltransferase

A

Phosphotidylcholine synthesis

22
Q

DGAT (acyl-CoA:diacylglycerol acyltransferase)

A

TAG synthesis

DAG»TAG

23
Q

Carbamoyl Phosphate Synthetase 1

A 
Urea cycle (rate-limiting step)
HCO3- + 2ATP + NH4+ >> Carbamoyl phosphate
24
Q

Aminolevulinine Acid (ALA) Synthase

A

Heme synthesis

succinyl-CoA + glycine&raquo_space; ALA

25
Q

Amidophosphoribosyltransferase

A 
Purine synthesis (committed step)
PRPP + Glutamine >> PRA + Glutamate
26
Q

IMP Dehydrogenase

A 
GMP synthesis (rate-limiting step)
IMP>>XMP
27
Q

Adenylosuccinate Synthetase

A 
AMP synthesis (rate-limiting step)
IMP>>adenylosuccinate
28
Q

Carbamoyl Phosphate Synthetase II

A

de novo pyrimidine synthesis

CO2 + 2 ATP + glutamine&raquo_space; carbamoyl phosphate + glutamate

Biochem Final (21 decks)

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