ALL

Question 1

1. ) The most common pediatric oncological disease?

2. ) solid tumor

Answer 1

1. ) ALL (25% of all malignancy)

2. ) brain tumor (gliomas)

Question 2

Symptoms of child with malignant disease

Answer 2

• fatigue, malaise, fever (general symptoms)

- look for these general symptoms over long periods of time

Question 3

What kind of pain is characteristic for malignancy

Answer 3

• wakes child up at night
• localized
• bone/leg pain (ALL)

Question 4

First thing to do with a child with ALL

Answer 4

CBC to look for leukocytosis.

If all 3 cell lines enhanced is suggestive.

Question 5

What is the second step for ALL

Answer 5

Look for LDH, uric acid or higher potassium (from cell damage)

Question 6

Look for symptoms for ALL

Answer 6

Enlarged lymph nodes, hepatosplenomegaly, petechia, and pallor from anemia

Question 7

After symptoms do a what to look for ALL

Answer 7

Bone marrow biopsy and blood smear (looking for lymphoblast)

Question 8

Where is the bone marrow biopsy taken from?

Answer 8

Posterior iliac crest

Question 9

What comes after the bone marrow biopsy

Answer 9

Genetic testing. Put in group (low, intermediate, high risk) determines amount of chemo later

Question 10

How do you check CNS for ALL

Answer 10

Lumbar puncture and follow up if there is need steroids and intrathecal chemotherapy

Question 11

First line therapy in leukemia last for

Answer 11

1 year

Question 12

How is the chemo administered in children

Answer 12

Not an IV needle (not peripheral since it isn’t safe). Give a central line (Porto-cath catheter).