All

Question 1

Streptozocin

Answer 1

MOA: similar structure to glucose. Taken up by GLUT 2 (panc B-cells) —> destroys panc B-cells —>
AE: DM, nephrogenic DI

Question 2

Octreotide

Answer 2

Somatostatin analog —> inhibits insulin, glucagon, GH, gastrin, motilin secretion
AE: anorexia, bradycardia

Question 3

Diazoxide

Answer 3

Inhibits release/ effects of insulin, stimulates hepatic gluconeogenesis
AE: hyperglycemia, DM, pancreatitis

Question 4

Trilostane

Answer 4

inhibits steroid synthesis (3-B-hydroxysteroid dehydrogenase) (blocks pregnenelone to progesterone)
AE: electrolyte abnormalities (hypoNa, hyperK) = aldosterone blockage
Hypoadrenocorticism

Question 5

Methimazole

Answer 5

Inhibits thyroperoxidase
AE: anorexia/V/D, abnormal vocalization, idiosyncratic hepatopathy, thrombocytopenia/neutropenia, facial excoriation

Question 6

Levothyroxine

Answer 6

Synthetic T4
AE: dermatitis, PU/PD

Question 7

Gabapentin

Answer 7

Blocks voltage gated Ca++ channels = decreases NT release (eg - glutamate)
AE: sedation

Question 8

Trazodone

Answer 8

Serotonin reuptake inhibitor + serotonin blocker (5HT2a and b)
AE: excitement, hepatotoxicity

Question 9

Zenalpha = medetomidine + vatinoxan

Answer 9

Alpha 2 + alpha 2 antagonist (to antagonize the CV effects of med)