Alcoholic Liver Disease and Consequences of Alcohol Flashcards
what are the acute affects of alcohol on the GI system?
oesophagitis, gastritir/ulceration
acute pancreatitis
what are the acute affects of alcohol on the respiratory system?
aspiration
which organs of the GI system are affected most by alcohol
liver, stomach and pancreas
what are the chronic affects of alcohol on the cardiovascular system?
Hypertension
Cardiomyopathy
Myocardial infarction
Stroke
what are the chronic affects of alcohol on the CNS system?
Neuropathies
Cerebellar degeneration
Dementia
Wernicke-Korsakoff’s syndrome
what are the chronic affects of alcohol on the haematologic system?
anaemia
bone marrow depression
what are the chronic affects of alcohol on the musculoskeletal system?
Proximal myopathy
Osteoporesis
Fatty alcoholic disease __%
Alcoholic hepatitis __-___%
cirrhotic changes __%
Fatty alcoholic disease 90%
Alcoholic hepatitis 10-30%
cirrhotic changes 30%
why is it called fatty liver disease?
When you consume alcohol it is metabolised into other toxic metabolites so there is increased peripheral release of fatty acids and increased synthesis of fatty acids and triglycerides within the liver cells
duration of drinking = 2-3 days
what is the change in the liver and is it reversible?
fatty liver - reversible
duration of drinking = 4-6 weeks
what is the change in the liver and is it reversible?
hepatitis - reversible
duration of drinking = months - years
what is the change in the liver and is it reversible?
fibrosis - irreversible
duration of drinking = years
what is the change in the liver and is it reversible?
cirrhosis - irreversible
what are the histological features of hepatitis - alcoholic
hepatocyte necrosis, neutrophils, mallory bodies and pericellular fibrosis
what are mallory bodies?
damaged intermediate filaments within the hepatocytes
clinical spectrum of symptoms
Malaise Nausea Hepatomegaly Fever Jaundice Sepsis Encephalopathy Ascites Renal Failure Death
what are biochem tests that indicate chronic liver disease?
prolonged prothrombin time, hypoalbuminaemia
how is cirrhosis graded
Childs-turcotte - pugh
Or model for end stage liver disease
biochem features of alcoholic hepatitis
Bilirubin > 80μmol/l
AST 1.5)
if someone comes in with transaminases in the 1000 what is the likely cause of hepatitis
more likely drugs or viral cause
what are the clinical features of alcoholic hepatitis?
hepatomegaly ± fever ± leucocytosis ± hepatic bruit
