Alcohol Use Disorder Flashcards
what effect does alcohol have on GABA
potentiates it
what effect does alcohol have on serotonin
reduces function
units =
ABV x volume of glass
What is central pontine myelinosis
white matter in brainstem affected, leads to pseudobulbar palsy, quadriplegia –> death
What is Marchiafava-Bignami disease
demyelination of corpus callosum
Three types of alcohol withdrawal syndrome
uncomplicated
AWS with seizures
delirium tremens
Uncomplicated AWS
4-12 hrs after last drink
coarse tremor, sweating, insomnia, nausea, vomiting
increased craving
peak at 48hrs, lasts 2-5 days
AWS with seizures
grand mal seizures
don’t signify the development of epilepsy
predisposing factors: previous Hx of them, epilepsy, head injury, hypokalaemia
Delirium tremens
acute confusional state medical emergency occurs within a week of last drink risk increased by: severe dependence, co-morbid infection, pre-existing liver damage
additional symptoms of delirium tremens
marked psychomotor agitation
hallucinations
persecutory delusions
febrile
treatment of wernicke-korsakoff syndrome
high potency parenteral vitamins
prophylaxis in detox
what is wernicke-korsakoff due to
it’s neuronal degeneration secondary to thiamine deficinecy
what is the wernicke encephalopathy tetrad
ACS
opthalmoplegia
nystagmus
ataxic gait
4 pharma treatments of alcohol use disorders
naltrexone
baclofen
acamprosate
disulfiram
what does disulfiram (antabuse) do
irreversible inhibition of acetaldehyde dehydrogenase (ALDH) which converts alcohol to CO2 and H2O
