Alcohol Flashcards
metabolism of alcohol
90% in liver
2-5 through sweat, urine, breath
GI issues and alcoholism
acute gastritis
GI bleeding
oesophageal, stomach, oral, bowel cancer
obesity
heart issues and alcoholism
hypertension
increased cholesterol
cardiomyopathy
cardiac arrhythmias
other issues with alcoholism
traumatic injuries
osteoporosis
gynae
chest
blood
mental health
renal
nervous system
bleeding and drug issues with alcoholism
bleeding, poor wound healing
drug metabolism, interactions, illicit drug mixing
oral problems with alcoholism
sialosis
xerostomia
ulceration, angular cheilitis, gingivitis
dental neglect
poor wound healing
suppression of immune system
erosion
bruxism
osteomyelitis
what is cirrhosis
late stage liver disease
scarring/fibrosis of liver tissue
makes - jaundice, ascites, bleeding, infections
causes of cirrhosis
chronic excessive drinking
Hep A/B
NAFLD
haemochromatosis
autoimmune hepatitis
why is liver disease so bad
- reduced synthesis of clotting factors in lover
- reduced absorption of vit K [II, VII, IX, X]
- thrombocytopenia due to splenomegaly associated with portal hypertension
- megakaryocyte maturation so fewer platelets
- platelet aggregation reduced
PROLONGED BLEEDING
drug metabolism and liver disease
reduced drug metabolism
increased blood concentration of drug
drugs to not give to pts with liver damage
disufilram
aspirin
NSAIDs
cardiomyopathy
degenerative heart disease
can lead to arrhythmias, cardiomegaly, congestive heart failure
need abstinence from alcohol
oral cancer and alcohol incidence reaction
promotes tobacco initiated tumours
damages DNA and alters oncogene production
facilitates absorption of carcinogenic across oral mucosa
partly due to thinning of oral mucosa due to nutritional deficiency
NCTSL and alcohol
very acidic
can cause GORD
vomiting
bruxism
SIGN guidelines 74 for management of harmful drinking and alcohol dependence in primary care
should opportunistically identify hazardous and harmful drinkers and deliver a brief [10 mins] intervention
