Alcohol Flashcards

1
Q

Why is the concentration of alcohol greater in the liver ?

A

Alcohol is absorbed in GI tract - stomach and small intestine - and absorbed into portal vein which goes straight to liver.

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2
Q

What drugs affect blood alcohol concentration ?

A

Antihistamines.
Cimetidine.

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3
Q

What enzyme will be increased in heavy drinkers ?

A

Gamma GT enzyme.

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4
Q

What percentage of alcohol is metabolised and excreted from liver ?

A

90%

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5
Q

What are patient factors which might influence alcohol metabolism ?

A

Age, gender, weight, previous exposure, food intake.

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6
Q

What is cimetidine effect on alcohol concentration ?

A

Increases absorption.

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7
Q

What is antihistamines effect on alcohol concentration ?

A

Decreases absorption.

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8
Q

What two factors make alcohol concentration higher in women ?

A

Reduced alcohol dehydrogenase enzyme in stomach - results in more absorption before metabolism.
Smaller blood volume.

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9
Q

What system is initiated in heavy drinkers ?

A

Microsomal ethanol oxidising system.

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10
Q

What is the safe weekly limit of alcohol ?

A

14 units spread across 3-4 days.

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11
Q

What is the legal driving limit of alcohol ?

A

80mg/100ml of blood.

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12
Q

What are the potential dental effects of vitamin deficiency (particularly B1, B2, B6, E and D) ?

A

Oral ulceration, glossitis, angular cheilitis, gingivitis.

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13
Q

What is the 3 blood related effects of alcohol ?

A

Thrombocytopenia, leucopenia, macrocytosis.

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14
Q

Name some dental effects of alcohol consumption.

A

Oral cancer.
Xerostomia.
Sialosis.
Caries.
Poor wound healing.
Osteomyelitis.
NCTSL.
OH and drug regime compliance.
Dental trauma.

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15
Q

What analgesia should be advised for patients who are heavy drinkers ?

A

Paracetamol (NSAIDs pose risk of gastric bleeding).

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16
Q

What should a patient who drinks heavily be warned of if they require metronidazole treatment ?

A

Nausea and vomitting.

17
Q

What is the mechanism of metronidazole’s action on alcohol ?

A

Inhibits alcohol dehydrogenase in stomach causing build up of acetylaldehyde = nausea.

18
Q

What are signs of alcoholic liver disease ?

A

Jaundice. Ascites. Cachexia. Enchephalopathy. Bleeding. Bruising.
Infection.

19
Q

If patient has no liver damage but drinks alcohol regularly - what outcome will it have on drug metabolism ?

A

Increased metabolism as liver enzymes are increased.

20
Q

If patient has liver damage but drinks alcohol regularly - what outcome will it have on drug metabolism ?

A

Reduced metabolism as liver enzymes are not being produced from fibrosed tissue.

21
Q

Patient has alcoholic liver disease, what LA should be used ?

A

Articaine.

22
Q

What % of people diagnosed with oral cancer consume alcohol ?

A

75-80%

23
Q

What is the survival rate % of oral cancer within 5 years ?

A

45-55%

24
Q

What are the 4 ways which alcohol (ethanol metabolite - acetylaldehyde) can cause oral cancer ?

A

Ethanol metabolite (acetylaldehyde) -
Promotes tobacco initiated tumours.
Facilitates carcinogenic absorption in oral mucosa.
Damages DNA.
Alters oncogene production.

25
Q

Name two questionnaires for assessment of alcohol intake.

A

FAST and AUDIT

26
Q

What alcohol assessment questionnaire is most commonly used in dentistry ?

A

FAST questionnaire.

27
Q

What is the function of alcohol assessment questionnaires ?

A

Identifies risk factors for dentist.
Identifies need for more comprehensive assessment for substance misuse.

28
Q

What are the five stages to the cycle of change ?

A

Precontemplative.
Contemplative.
Preparation.
Action.
Maintenance.
(Relapse).

29
Q

What type of intervention should a dentist take in alcohol prevention ?

A

Brief motivational interventions - opportunistic (5-20 mins) non-judgemental to encourage patient to recognise and differ actual and ideal behaviour with respect to alcohol intake.