AKI And CKD Flashcards
Functions of the kidneys
“A WET BED”: Acid-base balance, water balance, electrolyte balance, toxin removal, blood pressure control, erythropoietin, vitamin D metabolism
The _____ kidney sits lower than the _____ due to the location of the liver
Right; left
Pain while urinating
Dysuria
Excessive urination at night
Nocturia
Bloody urine
Hematuria
Abnormal amounts of protein in the urine
Proteinuria
Urine output <400 mL/day
Oliguria
Urine output <50 mL/day
Anuria
Normal urinary output
1-2 L/day or 30-50 mL/hr
Rate of blood flow through the kidneys
Glomerular Filtration Rate (GFR)
Expected GFR
90-120 mL/min
Best indicator of kidney function
Creatinine
End product of muscle metabolism; solely filtered from the blood via glomerulus
Creatinine
Creatinine expected range
0.6-1.2 mg/dL
Normal waste product resulting from the breakdown of proteins
Blood Urea Nitrogen (BUN)
BUN expected range
10-20 mg/dL
Lab that measures the kidney’s ability to excrete or conserve water
Urine specific gravity
Urine Specific Gravity expected range
1.010-1.030
Dilute urine _____ urine specific gravity, while concentrated urine _____ urine specific gravity
Decreases; increases
__________ is caused by inflammation and damage to the glomeruli as a result of formation of antigen-antibody complexes due to untreated strep infection
Acute Glomerulonephritis
S/S of glomerulonephritis
Hematuria, azotemia (resulting in tea-colored urine), retaining sodium, increased BP, edema (face and eyes)
Excessive nitrogenous waste in the blood
Azotemia
Labs associated with glomerulonephritis
Hypoalbuminemia, low GFR (oliguria), increased urine specific gravity, increased BUN and creatinine
Diet modifications for glomerulonephritis
Fluid and sodium restriction, low protein, high carb (provides energy and stops breakdown of protein)
Sudden renal damage causing a build-up of waste, fluid, and electrolyte imbalance; can be REVERSED
Acute Kidney Injury (AKI); aka acute renal failure
Damage before the kidneys
Prerenal failure
Decreased volume/perfusion to kidneys due to decreased or impaired CO (MI), vasodilation, hemorrhage (hypovolemia), burns, or GI losses such as V/D causes _____ failure
Prerenal
Damage in the kidneys
Intrarenal failure
Intrarenal failure results from
Prolonged ischemia
Examples of nephrotoxic drugs
NSAIDs, antibiotics (aminoglycosides), chemo drugs, contrast dyes
Damage after the kidneys
Postrenal failure
Postrenal failure results from
Obstruction/blockage in urinary tract (stones, blood clots, tumors, etc)
Phases of Acute Kidney Injury (AKI)
“Oh Oh Darn Renal”: onset/initiation, oliguria, diuretic, recovery
Onset/initiation phase of AKI
Triggering event (pre-intra-postrenal failure)
Oliguria phase of AKI is characterized by
Decreased UO (<400 mL/24 hrs), decreased GFR (d/t glomerulus decreasing ability to filter blood)
Phase of AKI in which the cause of AKI is corrected and UO gradually increases
Diuretic
AKI phase characterized by enhanced kidney function
Recovery
The recovery phase of AKI may take up to __-__ months
6-12
Treatment of the onset/initiation phase of AKI
Treat the cause
Interventions of oliguria phase of AKI
Diet modifications (low protein and fluid), strict I&O and daily weights, monitor EKG and labs (hyperkalemia), dialysis (until kidney function returns)
Labs associated with oliguria phase of AKI
Increased BUN, creatinine, and potassium
Hyponatremia, hypocalcemia
Interventions for diuretic phase of AKI
Monitor for dehydration and hypokalemia
Untreated AKI can lead to
Chronic Kidney Disease (CKD)
Protein that regulates oncotic pressure and prevents clot formation
Albumin
Condition in which kidneys release an excessive amount of protein (albumin) in urine
Nephrotic syndrome
S/S of nephrotic syndrome
Hypoalbuminemia (edema, fatigue, loss of appetite, hyperlipidemia), proteinuria (>3 g/day)
Interventions for nephrotic syndrome
Monitor fluid status (weights, I&O, edema), diet modifications, medications, monitor for signs of infection and blood clots, replace albumin!
Dietary modifications for nephrotic syndrome
Low cholesterol/saturated fats, low sodium, moderate protein
Medications for nephrotic syndrome
Diuretics, statins, prednisone (for inflammation), immunosuppressants
Progressive and irreversible loss of kidney function that occurs over a long period of time
Chronic Kidney Disease (CKD)
Causes of CKD
Untreated AKI, DM, HTN, recurrent infections, autoimmune disorders
Stages of CKD are based on
GFR (as CKD worsens, GFR decreases)