Aki Flashcards
Stage 1 AKI UO: <____ ml/kg per h for ___h
<0.5 ; 6-12
Stage 2 AKI UO
<____mL/kg per h for ____h
0.5 , 12
Pre renal AKI. 2 Reasons why BUN and SCr increases
Inadequate:
renal BF
Intraglomerular hydrostatic pressure
Prolonged Prerenal azotemia leads to
Acute tubular necrosis
A Decrease in CO leads to renal vasodilation/vasoconstriction? And salt and water reabsorption/excretion?
Constriction, reabsorption
Glomerular filtration is maintained despite reduced RBF by Ang2 mediated renal afferent/efferent vasodilation/vasoconstriction?
(Ipair mo sino mag dilate, constrict)
Efferent, constriction
Afferent, dilation
Renal autoregulation fails once SNP is below ____mmHg
80
NSAIDs inhibit the production of ____, limiting renal ______ vaso____
Prostaglandin
Afferent, vdilation
Therefore mag constrict sya
ARBS limit ____ vaso____
Efferent vasoconstriction therefore mag dilate sya
Most common causes of intrinsic AKI
1
2
3
Sepsis
Ischemia
Nephrotoxins
Kidneys receive __% CO and account for __% resting 02 consumption
20, 10
What segment of the proximal tubule is considered to be very metabolically active? S1, S2, S3?
S3
Mechanism of cardiopulmonary bypass in AKI. Give 1
Answers:
Hemolysis causing pigment nephropathy
Activation of leukocytes and inflammation
Aortic injury causing atheroemboli
Individuals undergoing massive fluid resuscitation for trauma, burns, and acute pancreatitis can also develop abdominal compartment syndrome, where markedly elevated intraabdominal pressures, usually >____mmHg, lead to renal vein compression and reduced GFR.
20
Contrast nephropathy
Rise in SCr beginning ___
Peaks in ___
Resolves within ____
Begins at 24-48 hrs
Peaks in 3-5 days
Resolves within 1 week
Electrolyte imbalance in AKI associated with antibiotic use
Hypomagnesemia
Most common protein in urine
Tamm-Horsfall or uromodulin from the TaL
Massive uric acid level. Give number
15 mg/dl
Electrolyte imbalance in multiple myeloma
Hypercalcemia
With many of the epithelial cell toxins such as aminoglycoside antibiotics and cisplatin, the rise in SCr is characteristically delayed for ____ to ___ after initial exposure.
3-5 days to 2 weeks
Hallmark of AKI
Increase BUN
Recovery from AKI is often heralded as
Increase in UO
Complication of AKI. Hyponat or hypernat
Hypo ofc
Complication of AKI. Hypo/hyper phosphatemia and hypo/hyper calcemia
Hyperphosphatemia
Hypocalcemia
