Ajuvants

Question 1

What is an adjuvant?

Answer 1

Any material that enhances the cellular and/or humoral immune response to an antigen.

Question 2

Why are adjuvants used in vaccines?

Answer 2

Used to facilitate the administration of reduced quantities of antigen while achieving an adequate immune response,
resulting in economic savings.

Question 3

What is the role of adjuvants in vaccine production?

Answer 3

Important in the production of subunit and vector vaccines
they help stimulate a stronger immunological response compared to vaccines administered without adjuvants.

Question 4

What are the characteristics of an ideal adjuvant?

Answer 4

• Safety (no unacceptable local/systemic responses)
• Elicit protective immunity even against weak immunogens
• Non-pyrogenic
• Chemically defined (QC testing)
• Effective in infants/young children
• Yield stable formulation with the antigen
• Biodegradable
• Non-immunogenic itself

Question 5

What type of adjuvants are routinely used in human medicine?

Answer 5

only aluminium-based in human medicine.

Question 6

How adjuvanticity often associated with toxicity?

Answer 6

The greater the adjuvanticity of a product, the more toxic it is likely to be.