AIRWAY Flashcards
General anesthetic two principal mechanisms
Increase in inhibition through activity at GABA receptors (benzos, barbs, propofol, etomidate, isoflurane, enflurane, halothane) and
Decreased excitation through NMDA receptors (ketamine, nitrous oxide, xenon)
Onset of unconsciousness in all induction agents minus midaz
30 seconds
Dosing of induction agents should be based on
LBW, decreasing to IBW if pt is hemodynamically compromised
Fatties 0.3 of excess body weight (TBW-IBW) added to IBW
1/2-1/3 in oldies due to extra fat, less muscle, less ability to compensate
Etomidate pharmacology
Hypnotic, no analgesic properties. Second most hemodynamically stable (next to ketamine)
Increases GABA. Attenuates ICP by decreasing CBF and CMRO2 (cerebral metabolic rate for oxygen)
Hemodynamically stable so preservers CPP
No histamine release
No bronchodilatory effect
Etomidate indications
Good for hemodynamic instability, or ICP because of decreased CMRO2 and CPP.
Pregnancy category C
Not FDA approved for peds but still probably okay for peds
Etomidate doses
0.3mg/kg
0.2mg/kg in hemodynamic compromised pts
Fatties do 0.3mg/kg plus 30% of TWB-IBW
Etomidate adverse
Pain on injection Myoclonic movements (don't matter but look like a seizure) Blockage of 11-B hydroxylase decreases serum cortisol and aldosterone
T1/2A and T1/2B
Distribution half life and elimination half life
Etomidate pharmacology
Onset 15-45 seconds
T1/2A 2-4 minutes
Duration 3-12 minutes
T1/2B 2-5 hours
Ketamine pharmacology
Onset 45-60 seconds
T1/2A 11-17 minutes
Duration 10-20 minutes
T1/2B 2-3 hours
Clonus
a series of involuntary, rhythmic, muscular contractions and relaxations.
Failed airway definition (3 things)
Failure to maintain acceptable O2 during or after one or more failed laryngoscopy attempts
Three failed attempts by an experienced provider even with proper oxygenation
Single best attempt at tubing fails in the “forced to act” scenario
Cormack and Lehane
Visualizing larynx during laryngoscopy. 3 and 4 are correlated with failed intubation
Grade 1 - Visualization of entire glotic aperture
Grade 2 - visualization of posterior portion of the cords or arytenoids
Grade 3 - only epiglottis visible
Grade 4 - No glottic structures visible
Cromack and Lehane Grade 2a/2b
2a shows an portion of the cords and 2b shows only arytenoids (2b airways behave more like 3)
LEMON
For identifying difficult intubations Look externally Evaluate 3-3-2 Mallampati score Obstruction/Obesity Neck mobility
L in LEMON
Look externally, if an airway looks difficult it probably is.
Overall feeling, things like lower facial disruption, bleeding, obese, agitated, short neck, small mouth etc.
E in LEMON
Evaluate 3-3-2. Based on angles for proper alignment to create a direct line of site.
Based on mouth opening wide enough for visualization, long enough mandible for tongue to be displaced, glottis is a sufficient distance caudad to the base of the tongue that cords can be visualized
Ludwigs angina
rare skin infection that occurs on the floor of the mouth, underneath the tongue. This bacterial infection often occurs after a tooth abscess, which is a collection of pus in the center of a tooth. It can also follow other mouth infections or injuries.
M in LEMON
Mallampati score
Class I and II are easy, IV may fail more than 10% of the time.