AIHA

Question 1

Autoantibodies become active and attack red blood cells only at temperatures below normal body temperature. (4C)

Answer 1

Cold Autoimmune Hemolytic Anemia

Question 2

Activation of **Complement system by IgM antibodies **resulting to cell lysis

Answer 2

Intravascular Hemolysis

Question 3

Recognition of C3b resulting to hemolysis occuring in the liver

Answer 3

Extravascular Hemolysis

Question 4

Caused by antibodies that optimally react at 4C

Answer 4

Cold Agglutinin Disease

Question 5

**Occurs in older population; peak incidence >50 yrs old

Answer 5

Cold Agglutinin Disease

Question 6

Can be caused by Mycoplasma pneumoniae or Infectious Mononucleosis

Answer 6

CAD

Question 7

If complement system fails to form membrane attack complex, complement proteins deposit on RBC surface

Answer 7

Extravascular Hemolysis

Question 8

IgM binds to polysaccharide region of glycoprotein on RBC surface complement system is triggered to lyse RBC

Answer 8

Intravascular Hemolysis

Question 9

A clinical manifestation of cold agglutinin disease

Answer 9

Reynaud’s Phenomenon

Question 10

Polychromasia,
Macrocytosis,
Spherocytosis,
Hyperbilirubinemia are laboratory findings in

Answer 10

Warm Autoimmune Hemolytic Anemia

Question 11

• Reticulocytosis
  * Positive DAT due to complement
• Agglutinated RBCs, Poikilocytosis, Anisocytosis

Answer 11

Cold Agglutinin Disease

Question 12

Aka secondary Cold AIHA.
Occurs as a transient disorder.
Secondary to infection.
Pallor and jaundice are characteristically present. Antibodies have anti-i specificity.

Answer 12

Cold Autoantibodies secondary to infxn.

Question 13

Treatment drug for Cold Autoantibodies Secondary to Infection

Answer 13

Chlorambucil 10mg OD

Question 14

often seen in children.
caused by **biphasic hemolysin. **
Anti-p specificity.
Donath Landsteiner antibody.

Answer 14

Paroxysmal Cold Hemoglobinuria

Question 15

cold temp fixes complement, Warm temp lyses RBC.

Answer 15

Paroxysmal Cold Hemoglobinuria

Question 16

Certain infections trigger antibody formation that reacts with the P antigen of RBC surface. After infection, polycolonal anti-P autoantibody binds to P antigen of RBC in cold temperature. When temperature is increased, complement system is activated and RBC is lysed.

Answer 16

Intravascular Hemolysis

Question 17

Paroxysmal Cold Hemoglibinuria Treatment that is the only useful therapy

Answer 17

Protection from cold exposure

Question 18

Following M. pneumoniae infection

Answer 18

CHD

Question 19

Following viral infection

Answer 19

PCH

Question 20

site of hemolysis of PCH

Answer 20

Intravascular

Question 21

Positive Donath-Landsteiner Test

Answer 21

PCH

Question 22

Treatment for PCH

Answer 22

Supportive

Question 23

monophasic antibody class

Answer 23

CHD

Question 24

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the autoantibodies attach to and destroy red blood cells at temperatures equal to or in excess of normal body temperature

It is the most common form of autoimmune hemolytic anemia

Answer 24

Warm Autoimmune Hemolytic Anemia

Question 25

Associated with collagen disease, SLE, RA, Carcinoma, Pregnancy

Answer 25

Warm Autoimmune Hemolytic Anemia

Question 26

Treatment for Warm Autoimmune Hemolytic Anemia when patient does not respond to prednisnone

Answer 26

Intravenous Immune Globulin (IVIG)

Question 27

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Drug does not bind covalently to RBCs but rather complexes with drug antibody

Answer 27

Drug-Induced Hemolytic Anemia - Neo antigen type

Question 28

occurs only when the patient receives massive doses of the antibiotic

Answer 28

Drug-Induced Hemolytic Anemia - Drug Adsorption Type

Question 29

Most frequently encountered drug in Drug-induced Hemolytic Anemia - Drug Adsorption Type

Answer 29

Cefotetan

Question 30

AIHA with variable complement activity

Answer 30

Warm-Reactive Autoantibody

Question 31

has specificity to Anti-Rh precursor, **anti-common Rh, anti-LW, anti-U **

Answer 31

Warm-reactive autoantibody AIHA

Question 32

site of RBC destruction wherein it is** predominantly in the spleen** with some liver involvement

Answer 32

Warm Reactive Autoantibody AIHA

Question 33

Quinidine and Phenacetin are under what mechanism of drug-related antibodies

Answer 33

Immune complex

Question 34

positive DAT only when drug is added to test system

Answer 34

Drug-induced hemolytic anemia - Autoimmune type