AI Hepatitis Flashcards
What is AI hepatitis?
Chronic hepatitis of unknown aetiology, characterised by auto-antibodies, hyperglobulinaemia (increased Ig) + inflammatory changes on liver histology
Describe the aetiology of AI hepatitis
Unknown, combination of:
Genetic predisposition
Environmental trigger: viruses, drugs
Autoantibodies
What are the 2 main types of AI hepatitis?
Type 1 (Classic)
ANA
ASMA
Anti-soluble liver antigen (anti-SLA)
Type 2
Antibodies to liver/kidney microsomes (ALKM-1)
Antibodies to liver cytosol antigen (ALC-1)
Describe the epidemiology of AI hepatitis
Type 1: occurs in ALL age groups (mainly young women)
Type 2: generally occurs in girls + young women
What 8 symptoms may a patient with AI hepatitis insidiously present with?
Malaise Fatigue Anorexia Weight loss Nausea Jaundice Amenorrhoea Epistaxis
List signs of AI hepatitis
Stigmata of chronic liver disease (e.g. spider naevi, hepatomegaly, jaundice)
Ascites, oedema + hepatic encephalopathy are late features
Cushingoid features (round face, acne, hirsuitism, cutaneous striae) may be present even before administration of steroids
How may AI hepatitis present?
Asymptomatically: incidental finding on LFTs
Insidiously
Acutely
List 6 symptoms of acute AI hepatitis
Fever Anorexia Jaundice N + V /Diarrhoea RUQ pain Serum sickness (e.g. arthralgia, polyarthritis, maculopapular rash)
What should be established in the history of a patient with AI hepatitis?
PMH/ FH of other AI conditions
Full hx to exclude viral/ alcoholic hepatitis
Describe LFTs in AI hepatitis
High: AST, ALT, GGT, ALP + BR
Low: albumin (in severe disease)
Clotting: High PT (in severe disease)
Describe bloods in AI hepatitis
Low Hb, platelets + WCC (if hypersplenism from portal HTN)
What other investigations are performed to exclude other caused of liver disease?
Viral serology (hep B/C)
Urinary copper/caeruloplasmin (Wilson’s disease)
Ferritin + transferrin saturation (haemochromatosis)
a-1 antitrypsin (for deficiency)
Anti-mitochondrial antibodies (PBC)
US, CT or MRI of liver + abdomen: Visualise structural lesions
ERCP: To exclude PSC
Why is a liver biopsy needed in AI hepatitis?
To establish a definitive dx + check whether hepatitis or cirrhosis
Hypergammaglobulinaemia is common in AI hepatitis, this is the presence of what?
ANA, ASMA + Anti-LKM antibodies